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TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial...
McNab, Finlay W.; Ewbank, John; Rajsbaum, Ricardo; Stavropoulos, Evangelos; Martirosyan, Anna; Redford, Paul S.; Wu, Xuemei; Graham, Christine M.Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of mortality and morbidity worldwide, causing ~1.4 million deaths per year. Key immune components for host protection during tuberculosis include the cytokines IL-12, IL-1, and TNF-a, as well as IFN-? and CD4(+) Th1 cells. However, immune factors determining whether individuals control infection or progress to active tuberculosis are in...
Date: 2013
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Origin: RepositóriUM - Universidade do Minho