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3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents fo...
Silva , V.; Benfeito, S.; Lima , C.; Chavarria, D.; Gonçalves, T.; Costa , I.; Remião , F.; Borges, F.; Silva , R.Background: Parkinson’s Disease (PD) is a multifactorial, complex and progressive neurodegenerative disease, characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta [1,2]. Several pathophysiological mechanisms are involved in PD, namely Lewy bodies formation, mitochondrial dysfunction, neuroinflammation, oxidative stress and iron accumulation within the brain [3]. Iron tr...
Date: 2023
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Origin: Scientific Letters