3 documents found, page 1 of 1
B Cell orchestration of anti-tumor immune responses: a matter of cell localizat...
Kinker, Gabriela Sarti; Vitiello, Glauco Akelinghton Freire; Ferreira, Wallax Augusto Silva; Chaves, Alexandre Silva; Lima, Vladmir Cl?udio Cordeiro deThis work was supported by funds from the S?o Paulo Research Foundation (FAPESP) to GK (fellowship 2019/25129- 2) and TM (grant 2018/14034-8), by the Coordination for the Improvement of Higher Education Personnel (CAPES) fellowship to AC, by grants from the National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation (INCITO) funded by FAPESP (grant 2014/50943-1), and the National Cou...
Challenging Mycobacterium tuberculosi s dormancy mechanisms and their immunodia...
Chaves, Alexandre Silva; Rodrigues, Michele Fernandes; Mattos, Ana Márcia Menezes; Teixeira, Henrique Couto-; Mycobacterium tuberculosis is the etiologic agent of tuberculosis, one of the world's greatest cause of morbidity and mortality due to infectious disease. Many evolutionary mechanisms have contributed to its high level of adaptation as a host pathogen. Prior to become dormant, a group of about 50 genes related to metabolic changes are transcribed by the DosR regulon, one of the most complex and important sys...
Efeito da proteína de fusão ESAT6:CFP10 e do antígeno recombinante Rv1733 na mo...
Chaves, Alexandre SilvaA tuberculose é uma doença infecciosa cujo principal agente etiológico é o Mycobacterium tuberculosis (Mtb). Macrófagos constituem a primeira linha de defesa contra a tuberculose, bem como o habitat preferencial para o Mtb. Antígenos específicos do Mtb tais como ESAT-6, CFP-10 e Rv1733 podem modular a produção de citocinas, influenciando o curso da infecção. Macrófagos infectados liberam uma grande quantidade d...