A doença pulmonar obstrutiva crónica é uma das principais causas de morbilidade e mortalidade, sendo a ventilação mecânica não invasiva (VMNI) um meio de intervenção. Tendo em conta a biomecânica da articulação, esta intervenção pode originar disfunção temporomandibular (DTM). Verificar a prevalência de DTM em indivíduos com doença pulmonar obstrutiva crónica. Secundariamente pretendeu-se avaliar a severidade ...
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Introduction – Chronic obstructive pulmonary disease is one of the main causes of morbidity and mortality, and non-invasive mechanical ventilation (NIMV) is a means of intervention. Taking into account the biomechanics of the Articulation this intervention can cause temporomandibular dysfunction (TMD). Objective – To verify the prevalence of TMD in individuals with chronic obstructive pulmonary disease. Seconda...
Background: In current guidelines, endoscopic ultrasound with fne-needle aspiration (EUS-FNA) is recommended in pancreatic cystic lesions (PCLs) with worrisome features (size≥3 cm, mural nodule, or Wirsung dilation). Objective: To evaluate the diagnostic ability and assess the accuracy of EUS-FNA in PCLs smaller than 3 cm. Methods: Retrospective study of PCLs<3 cm (2007–2016) undergoing EUS-FNA. Clinical, EUS a...
Background: Endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is recommended for diagnosis of pancreatic cystic lesions (PCLs). Its role in surveillance is unclear. Our goal was to determine if a second EUS-FNA changes diagnosis or management of PCLs. Methods: A retrospective analysis of an EUS database, searching for EUS-FNAs in PCLs from 2007 to 2017 was performed. Demographics, cyst characteristics...
Introdução: A Doença Pulmonar Obstrutiva Crónica é uma das principais causas de morbilidade e mortalidade, sendo a Ventilação Mecânica Não Invasiva (VMNI) um meio de intervenção. Tendo em conta a biomecânica da Articulação esta intervenção pode originar Disfunção Temporomandibular (DTM). Objetivo: Verificar a prevalência de DTM, avaliar a severidade de DTM associada ao número de horas/anos de utilização de VMNI...
Background: Carcinoembryonic antigen (CEA) and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic neoplasms. Genetic testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is unknown. Aim: To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for surgery...
Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in Barrett's esophagus tumorigenesis, a well-characterized multistep pathway of progression, from the premalignant condition to the metastatic disease. This human cancer model allows the study of sequential steps of progres...
Barrett's esophagus is the major risk factor for esophageal adenocarcinoma. It has a low but non-neglectable risk, high surveillance costs and no reliable risk stratification markers. We sought to identify early biomarkers, predictive of Barrett's malignant progression, using a meta-analysis approach on gene expression data. This in silico strategy was followed by experimental validation in a cohort of patients...
Wound healing is a complex process involving an integrated response by many different cell types and growth factors in order to achieve rapid restoration of skin architecture and function. The present study evaluated the applicability of a chitosan hydrogel (CH) as a wound dressing. Scanning electron microscopy analysis was used to characterize CH morphology. Fibroblast cells isolated from rat skin were used to...