116 documents found, page 1 of 12

Gene expression association study in feline mammary carcinomas

Works on cancer-related genes expression using feline mammary carcinomas (FMCs) are scarce but crucial, not only to validate these tumours as models for human breast cancer studies but also to improve small animal practice. Here, the expression of the cancer-related genes TP53, CCND1, FUS, YBX1, PTBP1, c-MYC and PKM2 was evaluated by real-time RT-qPCR, in a population of FMCs clinically characterized and compar...

Book of Abstracts of the Xth International Symposium on Wild Fauna(ISoWiF 2017)

Motor coordination, activity, and fitness at 6 years of age relative to activit...

Health benefits of physical activity (PA) and physical fitness (PF) are reasonably well established, but tracking studies of PA and PF in childhood have not ordinarily considered the role of motor coordination. Objectives: To compare the growth status, gross motor coordination (GMC), PA and PF characteristics of children at 6 years of age relative to aerobic fitness (fit, unfit) and PA (active, sedentary) at 10...

ERBB2 in Cat Mammary Neoplasias Disclosed a Positive Correlation between RNA an...

Human ERBB2 is a proto-oncogene that codes for the erbB-2 epithelial growth factor receptor. In human breast cancer (HBC), erbB-2 protein overexpression has been repeatedly correlated with poor prognosis. In more recent works, underexpression of this gene has been described in HBC. Moreover, it is also recognised that oncogenes that are commonly amplified or deleted encompass point mutations, and some of these ...

Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as...

Cancer cell lines have been shown to be reliable tools in genetic studies of breast cancer, and the characterization of these lines indicates that they are good models for studying the biological mechanisms underlying this disease. Here, we describe the molecular cytogenetic/genetic characterization of two sister rat mammary tumor cell lines, HH-16 cl.2/1 and HH-16.cl.4, for the first time. Molecular cytogeneti...

Sequence variants and Haplotype analysis of Cat ERBB2 Gene: a survey on spontan...

Sequence variation and mRNA expression of the TWIST1 gene in cats with mammary ...

New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation o...

Hepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year worldwide [1]. HCC is resistant to commonly used treatments like chemotherapy and radiotherapy and new anti-HCC therapies are urgently needed. Sorafenib was the first approved small molecule against HCC and underlines the importance of identifying potential new anti-HCC drugs [2]. Thirty-two 6-substituted methyl 3...

Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxici...

Hepatocellular carcinoma (HCC) is a highly complex cancer, resistant to commonly used treatments and new therapeutic agents are urgently needed. A total of thirty-two thieno[3,2-b]pyridine derivatives of two series: methyl 3-amino- -(hetero)arylthieno[3,2-b]pyridine-2-carboxylates (1ae1t) and methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates (2ae2n), previously prepared by some of us, w...

Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxici...