5 documents found, page 1 of 1
The PALliative MUlticenter Study in Intensive Care (PalMuSIC). Results From a M...
Correia, Iuri; Simas, Ângela; Chaves, Susana; Paixão, Ana Isabel; Catarino, Ana; Gonçalves-Pereira, JoãoObjective: Frailty is a clinically recognizable state of increased vulnerability common in critical medicine. When underrecognized, it may lead to invasive treatments that do not serve the patients’ best interest. Our aim was to evaluate the use of both palliative care consultation and invasive interventions in frail patients admitted to Intensive Care Units in Portugal. Methods: This was a prospective, observa...
Chronic Obstructive Pulmonary Disease Exacerbations in an Internal Medicine War...
Marote Correia, Luís; Chaves, Susana; Pestana, Andreia; Malheiro, Alexandra; Barros, Augusto; Brazão, Maria da LuzIntroduction: In Portugal, chronic obstructive pulmonary disease (COPD) affects around 14.2% of those older than 40 years. Internal Medicine plays a role in the hospitalized CODP exacerbation patient care. Our objective was to characterize the COPD exacerbation patients admitted to an Internal Medicine ward focusing on adverse outcome predictors.Methods: An observational retrospective study retrieved data from ...
Protocolos em Medicina Interna - Serviço de Medicina lnterna do Hospital Centra...
Brazão, Maria Luz Reis; Chaves, Susana; Claude, Jean; Sousa, João Adriano Rodrigues; Cardoso, Álmada; Chaves, Susana; Pestana, Andreia
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis thr...
Oliveira, Cláudia S. F.; Pereira, Helena Paula Fernandes; Alves, Sara Cristina Sequeira; Castro, Lisandra Marisa Flores; Baltazar, FátimaAcetate is a short-chain fatty acid secreted by Propionibacteria from the human intestine, known to induce mitochondrial apoptotic death in colorectal cancer (CRC) cells. We previously established that acetate also induces lysosome membrane permeabilization in CRC cells, associated with release of the lysosomal protease cathepsin D (CatD), which has a well-established role in the mitochondrial apoptotic cascade...
Bechcet´s Disease : an old illness with a new treatment?
Perneta, Filipe; Caldeira, Mónica; Chaves, Susana; Jardim, Margarida; Miranda, Rubina; Câmara, Margarida; Reis, Maria da Luz