8 documents found, page 1 of 1

Enhancement of acetate-induced apoptosis of colorectal cancer cells by cathepsi...

Colorectal cancer (CRC) is a leading cause of death worldwide. Conventional therapies are available with varying effectiveness. Acetate, a short-chain fatty acid produced by human intestinal bacteria, triggers mitochondria-mediated apoptosis preferentially in CRC but not in normal colonocytes, which has spurred an interest in its use for CRC prevention/therapy. We previously uncovered that acetate-induced mitoc...

Finding novel genes coding for eco-friendly surfactants from hypersaline Iberia...

Surfactants are tensioactive chemical compounds extensively used worldwide in a myriad of industrial sectors and in our daily lives, being present in numerous products including cosmetics, detergents, fabric softeners, toothpaste, among many others. Millions of tonnes of surfactants are thus manufactured every year. Most commercially available surfactants are non-renewable petroleum-based compounds that can hav...

A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as ri...

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies, which predominantly consist of aggregated forms of the protein alpha-synuclein (aSyn). While these aggregates are a pathological hallmark of PD, the etiology of most cases remains elusive. Although environmental risk factors have been identified, such as the pesticides diel...

Cymoxanil inhibits respiration through inhibition of mitochondrial complex IV

Cymoxanil is a synthetic acetamide fungicide, used against oomycetes. It was first introduced in 1977 and can be used against downy mildew diseases induced by Plasmopara viticola in grapevine cultures and late blight diseases caused by Phytophthora infestans, in tomatoes and potatoes cultures. This fungicide is used in mixed formulations and its higher solubility enables a relatively widespread occurrence in to...

Acetic acid triggers cytochrome c release in yeast heterologously expressing hu...

Proteins of the Bcl-2 protein family, including pro-apoptotic Bax and anti-apoptotic Bcl-xL, are critical for mitochondrial-mediated apoptosis regulation. Since yeast lacks obvious orthologs of Bcl-2 family members, heterologous expression of these proteins has been used to investigate their molecular and functional aspects. Active Bax is involved in the formation of mitochondrial outer membrane pores, through ...

How can a milk protein selectively kill cancer cells? Mechanisms underlying lac...

Lactoferrin (Lf) is an iron-binding protein abundant in milk that has been shown to exhibit anticancer activity. Since Lf is non-toxic to cancer cells (1) and is well tolerated in humans (2), this protein has a huge potential to be used in cancer therapy. However, the targets and mechanisms underlying its selective anticancer activity are poorly elucidated, which limits its clinical exploitation. The recruitmen...

Exploring a novel effect of lactoferrin on the plasma membrane towards the eluc...

Antibiotic free selection for the high level biosynthesis of a silk-elastin-lik...

Silk-elastin-like proteins (SELPs) are a family of genetically engineered recombinant protein polymers exhibiting mechanical and biological properties suited for a wide range of applications in the biomedicine and materials fields. They are being explored as the next generation of biomaterials but low productivities and use of antibiotics during production undermine their economic viability and safety. We have ...