2 documents found, page 1 of 1
Colorectal cancer-related mutant KRAS alleles function as positive regulators o...
Alves, Sara; Castro, Lisandra; Fernandes, Maria Sofia; Francisco, Rita; Castro, Paula; Priault, Muriel; Chaves, Susana Rodrigues; Moyer, Mary PatThe recent interest to modulate autophagy in cancer therapy has been hampered by the dual roles of this conserved catabolic process in cancer, highlighting the need for tailored approaches. Since RAS isoforms have been implicated in autophagy regulation and mutation of the KRAS oncogene is highly frequent in colorectal cancer (CRC), we questioned whether/how mutant KRAS alleles regulate autophagy in CRC and its...
Modulation of mitochondrial outer membrane permeabilization and apoptosis by ce...
Rego, António; Costa, Margarida; Chaves, Susana Rodrigues; Matmati, Nabil; Pereira, Helena; Sousa, Maria João; Moradas-Ferreira, Pedro; Hannun, Yusuf AThe yeast Saccharomyces cerevisiae undergoes a mitochondrial-dependent programmed cell death in response to different stimuli, such as acetic acid, with features similar to those of mammalian apoptosis. However, the upstream signaling events in this process, including those leading to mitochondrial membrane permeabilization, are still poorly characterized. Changes in sphingolipid metabolism have been linked to ...