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A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tubercu...

Bhatt, Kiranmai; Machado, Henrique Pedro Pereira Silva Amaral; Osório, Nuno S.; Sousa, Jeremy; Cardoso, Filipa; Magalhães, Carlos André Rodrigues

Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. Orthologous clusters are found in other slow-growing pathogenic mycobacteria ...

Date: 2018   |   Origin: RepositóriUM - Universidade do Minho
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