3 documents found, page 1 of 1
Regulation of invasion and peritoneal dissemination of ovarian cancer by mesoth...
Coelho, R; Ricardo, S; Amaral, AL; Huang, YL; Nunes, M; Neves, JP; Mendes, N; López, MN; Bartosch, C; Ferreira, V; Portugal, R; Lopes, JM; Almeida, RPeritoneal dissemination is a particular form of metastasis typically observed in ovarian cancer and the major cause for poor patient’s outcome. Identification of the molecular players involved in ovarian cancer dissemination can offer an approach to develop treatment strategies to improve clinical prognosis. Here, we identified mesothelin (MSLN) as a crucial protein in the multistep process of peritoneal disse...
Collagen-rich omentum is a premetastatic niche for integrin a2-mediated periton...
Huang, YL; Liang, CY; Ritz, D; Coelho, R; Septiadi, D; Estermann, M; Cumin, C; Rimmer, N; Schötzau, A; López, MN; Fedier, A; Konantz, M; Vlajnic, TThe extracellular matrix (ECM) plays critical roles in tumor progression and metastasis. However, the contribution of ECM proteins to early metastatic onset in the peritoneal cavity remains unexplored. Here, we suggest a new route of metastasis through the interaction of integrin alpha 2 (ITGA2) with collagens enriched in the tumor coinciding with poor outcome in patients with ovarian cancer. Using multiple gen...
Mucins and truncated O-glycans unveil phenotypic discrepancies between serous o...
Coelho, R; Marcos-Silva, N; Mendes, N; Pereira, D; Brito, C; Jacob, F; Steentoft, C; Mandel, U; Clausen, H; David, L; Ricardo, SOptimal research results rely on the selection of cellular models capable of recapitulating the characteristics of primary tumours from which they originate. The expression of mucins (MUC16 and MUC1) and truncated O-glycans (Tn, STn and T) represents a characteristic footprint of serous ovarian carcinomas (SOCs). Therefore, selecting ovarian cancer (OVCA) cell lines that reflect this phenotype is crucial to exp...