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Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunct...

Nunes, João Paulo Silva; Andrieux, Pauline; Brochet, Pauline; Almeida, Rafael Ribeiro; Kitano, Eduardo; Honda, André Kenji; Iwai, Leo Kei

Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million people worldwide, and chronic production of the cytokines IFN-γ and TNF-α by T cells together with mitochondrial dysfunction are important players for the poor prognosis of the disease. Mitochondria occupy 40% of the cardiomyocytes volume a...






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