26 documents found, page 1 of 3
Early polymerase chain reaction detection of Chagas disease reactivation in hea...
Costa, Priscilla Almeida da; Segatto, Marcela [UNESP]; Durso, Danielle Fernandes; Carvalho Moreira, Wagson Jose de; Junqueira, Lucas LodiMade available in DSpace on 2018-11-26T15:44:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-07-01; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Departamento de Ciencia e Tecnologia do Ministerio da Saude (Decit/SCTIE/MS); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); BACKGROUND: Heart tr...
II Consenso Brasileiro em Doen?a de Chagas, 2015
Dias, Jo?o Carlos Pinto; Ramos Jr, Alberto Novaes; Gontijo, Eliane Dias; Luquetti, Alejandro; Shikanai-Yasuda, Maria Aparecida; Coura, Jos? RodriguesProjeto financiado pela Unidade T?cnica de Vigil?ncia das Doen?as de Transmiss?o Vetorial, Secretaria de Vigil?ncia em Sa?de, Minist?rio da Sa?de do Brasil, Bras?lia-DF.; Funda??o Oswaldo Cruz. Centro de Pesquisas Ren? Rachou. Belo Horizonte, MG, Brasil.; Universidade Federal do Cear?. Faculdade de Medicina. Fortaleza, CE, Brasil.; Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG,...
2nd Brazilian Consensus on Chagas Disease, 2015
Dias, Jo?o Carlos Pinto; Ramos, Alberto Novaes; Gontijo, Eliane Dias; Luquetti, Alejandro; Shikanai-Yasuda, Maria Aparecida; Coura, Jos? RodriguesFunda??o Oswaldo Cruz. Centro de Pesquisa Ren? Rachou. Belo Horizonte, MG, Brasil.; Universidade Federal do Cear?. Faculdade de Medicina. Fortaleza, CE, Brasil.; Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brasil.; Universidade Federal de Goi?s. Instituto de Patologia Tropical e Sa?de P?blica. Goi?nia, GO, Brasil.; Universidade de S?o Paulo. Faculdade de Medicina. S?o Paulo,...
Variation in susceptibility to benznidazole in isolates derived from Trypanosom...
Veloso, Vanja Maria; Toledo, Max Jean de Ornelas; Lana, Marta de; Chiari, Egler; Tafuri, Washington Luiz; Bahia, Maria TerezinhaIn this work, the susceptibility to benznidazole of two parental Trypanosoma cruzi strains, Colombian and Berenice-78, was compared to isolates obtained from dogs infected with these strains for several years. In order to evaluate the susceptibility to benznidazole two groups of mice were infected with one of five distinct populations isolated from dogs as well as the two parental strains of T. cruzi. The first...
Hematological alterations during experimental canine infection by Trypanosoma c...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Mineo, Tiago Wilson Patriarca; Silva, Juliana Santiago; Crepalde, Geovam PereiraPara confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosoma cruzi, correlacionando os sinais clínicos com a curva de parasitemia. Foi demonstrado que a fase aguda da infecção foi marcada por letargia e perda de apetite. Simultaneamente, obser...
Inflammation enhances the risks of stroke and death in chronic chagas disease p...
Guedes, Paulo Marcos da Matta; Andrade, Cléber Mesquita de; Nunes, Daniela Ferreira; Pereira, Nathalie de Sena; Queiroga, Tamyres Bernadete DantasIschemic strokes have been implicated as a cause of death in Chagas disease patients. Inflammation has been recognized as a key component in all ischemic processes, including the intravascular events triggered by vessel interruption, brain damage and repair. In this study, we evaluated the association between inflammatory markers and the death risk (DR) and stroke risk (SR) of patients with different clinical f...
Increased type 1 chemokine expression in experimental Chagas disease correlates...
Guedes, Paulo Marcos da Matta; Veloso, Vanja Maria; Silva, André Talvani Pedrosa da; Diniz, Lívia de Figueiredo; Caldas, Ivo SantanaChemokines and chemokine receptors interaction have presented important role in leukocyte migration to specific immune reaction sites. Recently, it has been reported that chemokine receptors CXC (CXCR3) and CC (CCR5) were preferentially expressed on Th1 cells while CCR3 and CCR4 were preferentially expressed on Th2 cells. This study evaluated the mRNA expression of type 1 and type 2 chemokine and chemokine rece...
Synthesis and trypanocidal activity of ent-kaurane glycosides.
Batista, Ronan; Humberto, Jorge Luiz; Chiari, Egler; Oliveira, Alaíde Braga deNovel ent-kaurane glucosides were synthezised by a Koenigs–Knorr reaction between C17 and C19 alcohols derived from kaurenoic acid and 2,3,4,6-tetra-O-acetyl-glucopyranosyl bromide, followed by the hydrolysis of the acetates. Main products were assayed in vitro and in vivo against blood trypomastigote forms of Trypanosoma cruzi, the aetiological agent of Chagas’ disease (American trypanosomiasis). The results a...
Genetic profiling of Trypanosoma cruzi directly in infected tissues using neste...
Pimenta, Juliana Ramos; Freitas, Jorge Marcelo de; Duffy, Tomás; Bartholomeu, Daniella Castanheira; Oliveira, Riva de Paula; Chiari, EglerThe investigation of the importance of the genetics of Trypanosoma cruzi in determining the clinical course of Chagas disease will depend on precise characterisation of the parasites present in the tissue lesions. This can be adequately accomplished by the use of hypervariable nuclear markers such as microsatellites. However the unilocal nature of these loci and the scarcity of parasites in chronic lesions make...
Unequivocal identification of subpopulations in putative multiclonal Trypanosom...
Valadares, Helder Magno Silva; Pimenta, Juliana Ramos; Segatto, Marcela; Veloso, Vanja Maria; Gomes, Mônica Lúcia; Chiari, Egler; Gollob, Kenneth JohnTrypanosoma cruzi, the etiological agent of Chagas disease, is a polymorphic species. Evidence suggests that the majority of the T. cruzi populations isolated from afflicted humans, reservoir animals, or vectors are multiclonal. However, the extent and the complexity of multiclonality remain to be established, since aneuploidy cannot be excluded and current conventional cloning methods cannot identify all the r...