6 documents found, page 1 of 1
The transcription factor CgHaa1 plays a role in virulence of the pathogenic yea...
Salazar, Sara Barbosa; Pedro, Nuno Alexandre; Silva, Sónia Carina; Mil-Homens, Dalila; Pimenta, Andreia; Wlodarczyk, Marcin; Szwed-Georgiou, AleksandraCandida glabrata is a prominent causative agent of mucosal and disseminated human infections. Part of the success of C. glabrata as a human pathogen relies on its adherence capacity and ability to tolerate/surpass the activity of immune cells. Herein we describe the involvement of the transcription factor CgHaa1 and of its regulated genes CgAWP12, CgAWP13, CAGL0H07469 g, and CAGL0K10164 g in adherence of C. gla...
The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Pereira, L. P.; Silva, Sónia Carina; Salazar, Sara B.; Schröder, Markus S.; Okamoto, MichiyoTo thrive in the acidic vaginal tract C. glabrata has to cope with high concentrations of acetic acid. The mechanisms underlying C. glabrata tolerance to acetic acid at low pH remain largely uncharacterized. In this work it is demonstrated the essential role of the CgHaa1 transcription factor (encoded by ORF CAGL0L09339g) in the response and tolerance of C. glabrata to acetic acid. Transcriptomic analysis showe...
Genetic adaptive mechanisms mediating response and tolerance to acetic acid str...
Salazar, Sara; Bernardes, Rúben; Cunha, Diana; Chibana, Hiroji; Azeredo, Joana; Butler, Geraldine; Mira, Nuno P.The increased resilience of Candida glabrata to azoles and the continuous emergence of strains resistant to other antifungals demands the development of new therapeutic approaches focused on non-conventional biological targets. Genes contributing to increase C. glabrata competitiveness in the different infection sites are an interesting and unexplored cohort of therapeutic targets. To thrive in the vaginal trac...
Genetic adaptive mechanisms mediating response and tolerance to acetic acid str...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Chibana, Hiroji; Silva, Sónia Carina; Sá-Correia, Isabel; Azeredo, Joana; Butler, GeraldineC. glabrata is a commensal found in the human genitourinary tract but under certain conditions this harmless colonization evolves to a mucosal infection and, in more serious cases, to disseminated mycosis. To thrive in the acidic vaginal tract C. glabrata has to cope with the presence of a competing commensal microbiota known to restrain the overgrowth of pathogens through the production of acetic and lactic ac...
Genetic adaptive mechanisms mediating response and tolerance to acetic acid str...
Mira, N. P.; Bernado, R.; Cunha, D.; Wang, C. A. N.; Chibana, Hiroji; Silva, Sónia Carina; Sá-Correia, I.; Azeredo, Joana; Butler, G.Background and objectives C. glabrata is a commensal found in the human genitourinary tract but under certain conditions this harmless colonization evolves to a mucosal infection and, in more serious cases, to disseminated mycosis. To thrive in the acidic vaginal tract C. glabrata has to cope with the presence of a competing com- mensal microbiota that restrains the overgrowth of pathogens by producing acetic a...
The CgHaa1-dependent pathway mediates Candida glabrata response and tolerance t...
Bernardo, Ruben; Silva, Sónia Carina; Cunha, Diana V.; Pereira, Leonel; Wang, Can; Correia, Isabel Sá; Chibana, Hiroji; Butler, GeraldineTo successfully colonize the vaginal tract Candida glabrata has to cope with various stresses including the presence of acetic acid at a low pH that is produced by the bacteria that co-colonize this niche. The genes/pathways involved in C. glabrata tolerance and response to acetic acid are largely unknown, although these are a highly interesting set of novel targets to control vaginal infections caused by this ...