9 documents found, page 1 of 1
New Lager Brewery Strains obtained by crossing techniques using cachaça (Brazil...
Queiroz, Marisa Vieira de; Figueiredo, Bruna Inez Carvalho; Saraiva, Margarete Alice Fontes; Pimenta, Paloma Patrick de SouzaThe development of hybrids has been an effective approach to generate novel yeast strains with optimal technological profile for use in beer production. This study describes the generation of a new yeast strain for lager beer production by direct mating between two Saccharomyces cerevisiae strains isolated from cachaça distilleries: one that was strongly flocculent, and the other with higher production of aceta...
Leishmania amazonensis-induced caMP triggered by adenosine a2B receptor is impo...
Figueiredo, Amanda Braga de; Testasicca, Miriam Conceição de Souza; Mineo, Tiago Wilson Patriarca; Afonso, Luís Carlos CroccoDifferently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses. Dendritic cells (DC) are essential for the innate immune response and for directing the differentiation of T-helper lymphocytes. Previously, we showed that L. amazonensis infection impairs DC activation through the activation of adenosine A2B receptor, an...
Sensitive and specific serodiagnosis of Leishmania infantum infection in dogs u...
Chávez Fumagalli, Miguel Angel; Martins, Vívian Tamietti; Testasicca, Miriam Conceição de Souza; Lage, Daniela Pagliara; Costa, Lourena EmanueleIn Brazil, the percentage of infected dogs living in areas where canine visceral leishmaniasis (CVL) is endemic ranges from 10 to 62%; however, the prevalence of infection in dogs is probably higher than figures reported from serological studies. In addition, problems with the occurrence of false-positive or false-negative results in the serodiagnosis of CVL have been reported. The present work analyzed the pot...
Purinergic signaling and infection by Leishmania : a new approach to evasion of...
Figueiredo, Amanda Braga de; Testasicca, Miriam Conceição de Souza; Afonso, Luís Carlos CroccoInfection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruc...
The influence of ecto-nucleotidases on Leishmania amazonensis infection and imm...
Testasicca, Miriam Conceição de Souza; Assis, Elisângela Aparecida de; Gomes, Rodrigo Saar; Silva, Eduardo de Almeida Marques da; Melo, Maria NormaPrevious results from our laboratory and from the literature have implicated the expression of ectonucleotidases in the establishment of Leishmania infection. In the present study we evaluated the correlation between ecto-nucleotidasic activity and the infectivity of L. amazonensis promastigotes that were kept in culture for short or extended numbers of passages, a condition that is known to decrease parasite i...
Association of liposome-encapsulated trivalent antimonial with ascorbic acid: a...
Castro, Renata Alves de Oliveira e; Barcellos, Neila Marcia Silva; Licio, Carolina Souza Andrade; Souza, Janine Braga deVisceral leishmaniasis (VL) is a chronic debilitating disease endemic in tropical and subtropical areas, caused by protozoan parasites of the genus Leishmania. Annually, it is estimated the occurrence of 0.2 to 0.4 million new cases of the disease worldwide. Considering the lack of an effective vaccine the afflicted population must rely on both, an accurate diagnosis and successful treatment to combat the disea...
Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associ...
Grenfell, Rafaella Fortini Queiroz; Silva, Eduardo de Almeida Marques da; Testasicca, Miriam Conceição de Souza; Coelho, Eduardo Antônio FerrazThis study evaluated two vaccine candidates for their effectiveness in protecting BALB/c mice against Leishma¬nia chagasi infection. These immunogenic preparations were composed of Leishmania amazonensis or Leishmania braziliensis antigenic extracts in association with saponin adjuvant. Mice were given three subcutaneous doses of one of these vaccine candidates weekly for three weeks and four weeks later challe...
Antibody responses induced by Leish-Tec®, an A2-basedvaccine for visceral leish...
Testasicca, Miriam Conceição de Souza; Santos, Mariana Silva dos; Machado, Leopoldo Marques; Serufo, Ângela Vieira; Doro, Daniel; Avelar, DanielZoonotic visceral leishmaniasis (VL) is a widespread disease, and dogs are the main reser-voirs for human parasite transmission. Hence, development of an effective vaccine thatprevents disease and reduces the transmission of VL is required. As euthanasia of seropos-itive dogs is recommended in Brazil for VL epidemiological control, to include anti-VLcanine vaccines as a mass control measure it is necessary to c...
Características da resposta imune desenvolvida frente à infecção por Leishmania...
Testasicca, Miriam Conceição de SouzaDiferentes espécies de parasitos do gênero Leishmania causam infecções expressivamente distintas em uma mesma espécie de hospedeiro. Enquanto alguns hospedeiros são resistentes à infecção por diversas espécies do parasito, quase todas as linhagens de camundongos são susceptíveis à infecção por L. amazonensis, desenvolvendo lesões crônicas e progressivas em resposta à infecção. Esta pronunciada virulência dos pa...