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Prognostic Significance of Subtle Coronary Calcification in Patients with Zero ...

Han, D; Klein, E; Friedman, J; Gransar, H; Achenbach, S; Al-Mallah, M; Budoff, M; Cademartiri, F; Maffei, E; Callister, T; Chinnaiyan, K; Chow, B

Background and aims: The Agatston coronary artery calcium score (CACS) may fail to identify small or less dense coronary calcification that can be detected on coronary CT angiography (CCTA). We investigated the prevalence and prognostic importance of subtle calcified plaques on CCTA among individuals with CACS 0. Methods: From the prospective multicenter CONFIRM registry, we evaluated patients without known CAD...


Prognostic Value of Age Adjusted Segment Involvement Score As Measured by Coron...

Ayoub, C; Kritharides, L; Yam, Y; Chen, L; Hossain, A; Achenbach, S; Al-Mallah, M; Andreini, D; Berman, D; Budoff, M; Cademartiri, F; Callister, T

Extent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT ...


Long-Term Prognostic Impact of CT-Leaman Score in Patients with Non-Obstructive...

Andreini, D; Pontone, G; Mushtaq, S; Gransar, H; Conte, E; Bartorelli, AL; Pepi, M; Opolski, M; Ó Hartaigh, B; Berman, D; Budoff, M; Achenbach, S

BACKGROUND: Non-obstructive coronary artery disease (CAD) identified by coronary computed tomography angiography (CCTA) demonstrated prognostic value. CT-adapted Leaman score (CT-LeSc) showed to improve the prognostic stratification. Aim of the study was to evaluate the capability of CT-LeSc to assess long-term prognosis of patients with non-obstructive (CAD). METHODS: From 17 centers, we enrolled 2402 patients...


Impact of Age and Sex on Left Ventricular Function Determined by Coronary Compu...

Gebhard, C; Buechel, RR; Stähli, BE; Gransar, H; Achenbach, S; Berman, DS; Budoff, MJ; Callister, TQ; Chow, B; Dunning, A; Al-Mallah, MH; Cademartiri, F

BACKGROUND: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking. METHODS AND RESULTS: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outco...


Predictive Value of Age- and Sex-Specific Nomograms of Global Plaque Burden on ...

Naoum, C; Berman, D; Ahmadi, A; Blanke, P; Gransar, H; Narula, J; Shaw, LJ; Kritharides, L; Achenbach, S; Al-Mallah, M; Andreini, D; Budoff, MJ

Background: Age-adjusted coronary artery disease (CAD) burden identified on coronary computed tomography angiography predicts major adverse cardiovascular event (MACE) risk; however, it seldom contributes to clinical decision making because of a lack of nomographic data. We aimed to develop clinically pragmatic age- and sex-specific nomograms of CAD burden using coronary computed tomography angiography and to v...


Sex-Specific Associations Between Coronary Artery Plaque Extent and Risk of Maj...

Schulman-Marcus, J; Hartaigh, B; Gransar, H; Lin, F; Valenti, V; Cho, I; Berman, D; Callister, T; DeLago, A; Hadamitzky, M; Hausleiter, J; Al-Mallah, M

OBJECTIVES: The purpose of this study was to examine sex-specific associations, if any, between per-vessel coronary artery disease (CAD) extent and the risk of major adverse cardiovascular events (MACE) over a 5-year study duration. BACKGROUND: The presence and extent of CAD diagnosed by coronary computed tomography angiography (CTA) is associated with increased short-term mortality and MACE. Nevertheless, some...


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