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Data driven diagnostic classification in Alzheimer's disease based on different...

Oliveira, Francisco; Leuzy, Antoine; Castelhano, J.; Chiotis, Konstantinos; Hasselbalch, Steen Gregers; Rinne, Juha; Mendonça, Alexandre de

Positron emission tomography (PET) neuroimaging with the Pittsburgh Compound_B (PiB) is widely used to assess amyloid plaque burden. Standard quantification approaches normalize PiB-PET by mean cerebellar gray matter uptake. Previous studies suggested similar pons and white-matter uptake in Alzheimer's disease (AD) and healthy controls (HC), but lack exhaustive comparison of normalization across the three regio...

Date: 2018   |   Origin: Estudo Geral - Universidade de Coimbra
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