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Integration of microfluidics and nanoezyme peroxidase for colorimetric detectio...

Sousa, Cristina; Chiussi, Stefano; Moreira, Felismina T.C.

The integration of Microfluidics and Nanozyme peroxidase for the Colorimetric detection of Neurotransmitters represents a cutting-edge approach in neurochemical analysis. Microfluidics allows precise manipulation of small fluid volumes, reducing reagent consumption and accelerating reactions while integrating multiple analytical steps on a single chip. Nanozyme peroxidases, mimicking natural peroxidases, provid...


Flexible sensing devices integrating molecularly-imprinted polymers for the det...

Martins, Gabriela V.; Riveiro Rodriguez, Antonio; Chiussi, Stefano; Sales, Goreti

In recent years, the development of flexible and wearable devices for healthcare and biomedical applications has become an emerging technological goal, particularly with personalized medicine on the rise. As a response to the increasing demand for in-situ sensing platforms that fulfil some essential requirements like sensitivity, reproducibility and high stability, electrochemical sensors have boosted their way...


Study on excimer laser irradiation for controlled dehydrogenation and crystalli...

Gontad, F.; Filonovich, Sergej; Cerqueira, M. F.; Alpuim, P.; Chiussi, Stefano

We report on the excimer laser annealing (ELA) induced temperature gradients, allowing controlled crystal-lization and dehydrogenation of boron-doped a-Si:H/nc-Si:H multilayers. Depth of the dehydrogenation and crystallization process has been studied numerically and experimentally, showing that temperatures below the monohydride decomposition can be used and that significant changes of the doping profile can be ...


Improvement of electrospun polymer fiber meshes pore size by femtosecond laser ...

Rebollar, Esther; Cordero, Diego; Martins, Albino; Chiussi, Stefano; Reis, R. L.; Neves, N. M.; Leon, Bétty

Polymer meshes have recently attracted great attention due to their great variety of aplications in fields such as tissue engineering and drug delivery. Poly( -caprolactone) nanofibers were prepared by electrospinning giving rise to porous meshes. However, for some applications in tissue engineering where, for instance, cell migration into the inner regions of the mesh is aimed, the pore size obtained by conven...


Surface modification of a biodegradable composite by UV laser ablation : in vit...

Martins, Albino; Gang, Wu; Pinho, Elisabete D.; Rebollar, Esther; Chiussi, Stefano; Reis, R. L.; Leon, Betty; Neves, N. M.

Melt blends of chitosan and biodegradable aliphatic polyester have been physically and biologically studied, presenting great potential for biomedical applications. Structurally, poly(butylene succinate)–chitosan (PBS/Cht) composite scaffolds are covered by a thin PBS layer, preventing the desired interaction of cells/tissues with the chitosan particules. In the present work, a selective and controlled ablation...


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