32 documents found, page 1 of 4
Natural products-based antiangiogenic agents: new frontiers in cancer therapy
Azevedo, T; Ferreira, T; Pena-Corona, SI; Cortes, H; Silva-Reis, R; Gil da Costa, RM; Faustino-Rocha, Ana I; Oliveira, PA; Calina, D; Cardoso, MAngiogenesis, vital for tumor growth and metastasis, is a promising target in cancer therapy. Natural compounds offer potential as antiangiogenic agents with reduced toxicity. This review provides a comprehensive overview of natural product-based antiangiogenic therapies, focusing on molecular mechanisms and therapeutic potential. A systematic search identified relevant articles from 2019 to 2023. Various natur...
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: E...
Taheri, Y; Sharifi-Rad, J; Antika, G; Yilmaz, YB; Tumer, TB; Abuhamdah, S; Chandra, S; Saklani, S; Kiliç, CS; Sestito, S; Dastan, SD; Kumar, MLuteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, a...
Green Synthesized Silver Nanoparticles as Potent Antifungal Agent against Asper...
Anum, F; Jabeen, K; Javad, S; Iqbal, S; Tahir, A; Javed, Z; Martins, N; Ayatollahi, SA; Sharifi-Rad, J; Alshehri, MM; Cho, WCMedicinal plants are composed of a rich pool of biomolecules and have been increasingly recognized for their antimicrobial properties; however, increasing concerns have been put on the bioavailability features. Thus, this study is aimed at exploring the synthesis and characterization of silver nanoparticles synthesized by Chenopodium album L. leaf extract and assessing the antifungal activity against Aspergillu...
Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Mole...
Sharifi-Rad, J; Martins, N; López-Jornet, P; Lopez, EPF; Harun, N; Yeskaliyeva, B; Beyatli, A; Sytar, O; Shaheen, S; Sharopov, F; Taheri, Y; Docea, AOCoumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensi...
Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects
Asgharian, P; Tazehkand, AP; Soofiyani, SR; Hosseini, K; Martorell, M; Tarhriz, V; Ahangari, H; Martins, N; Sharifi-Rad, J; Almarhoon, ZM; Ydyrys, APancreatic cancer (PC) is a lethal malignancy cancer, and its mortality rates have been increasing worldwide. Diagnosis of this cancer is complicated, as it does not often present symptoms, and most patients present an irremediable tumor having a 5-year survival rate after diagnosis. Regarding treatment, many concerns have also been raised, as most tumors are found at advanced stages. At present, anticancer com...
Cyperus spp.: A Review on Phytochemical Composition, Biological Activity, and H...
Taheri, Y; Herrera-Bravo, J; Huala, L; Salazar, LA; Sharifi-Rad, J; Akram, M; Shahzad, K; Melgar-Lalanne, G; Baghalpour, N; Tamimi, KCyperaceae are a plant family of grass-like monocots, comprising 5600 species with a cosmopolitan distribution in temperate and tropical regions. Phytochemically, Cyperus is one of the most promising health supplementing genera of the Cyperaceae family, housing ˜950 species, with Cyperus rotundus L. being the most reported species in pharmacological studies. The traditional uses of Cyperus spp. have been report...
Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredient...
Sharifi-Rad, J; Quispe, C; Zam, W; Kumar, M; Cardoso, SM; Pereira, OR; Ademiluyi, AO; Adeleke, O; Moreira, AC; Živkovic, J; Noriega, F; Ayatollahi, SACardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor-alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and ...
Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Base...
Hossain, R; Quispe, C; Herrera-Bravo, J; Islam, MS; Sarkar, C; Islam, MT; Martorell, M; Martins, N; Al-Harrasi, A; Al-Rawahi, A; Sharifi-Rad, JLasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, a...
Chemical Composition, Biological Activity, and Health-Promoting Effects of With...
Sharifi-Rad, J; Quispe, C; Ayatollahi, SA; Kobarfard, F; Staniak, M; Stepien, A; Czopek, K; Sen, S; Acharya, K; Matthews, KR; Sener, B; Devkota, HPThe Withania genus comes from the Solanaceae family and includes around 23 species, spread over some areas of the Mediterranean, Asia, and East Africa. Widely used in traditional medicine for thousands of years, these plants are rich in secondary metabolites, with special emphasis on steroidal lactones, named withanolides which are used as ingredients in numerous formulations for a plethora of diseases, such as...
Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
Alshehri, MM; Sharifi-Rad, J; Herrera-Bravo, J; Jara, EL; Salazar, LA; Kregiel, D; Uprety, Y; Akram, M; Iqbal, M; Martorell, M; Torrens-Mas, M; Pons, DGDaidzein is a phytoestrogen isoflavone found in soybeans and other legumes. The chemical composition of daidzein is analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases, especially those associated with the control of estr...