7 documents found, page 1 of 1
Evolutionarily conserved role of oxytocin in social fear contagion in zebrafish
Akinrinade, Ibukun; Kareklas, Kyriacos; Teles, Magda C; Reis, Thais K.; Gliksberg, Michael; Petri, Giovanni; Levkowitz, Gil; Oliveira, Rui F.Emotional contagion is the most ancestral form of empathy. We tested to what extent the proximate mechanisms of emotional contagion are evolutionarily conserved by assessing the role of oxytocin, known to regulate empathic behaviors in mammals, in social fear contagion in zebrafish. Using oxytocin and oxytocin receptor mutants, we show that oxytocin is both necessary and sufficient for observer zebrafish to imi...
Perceptual mechanisms of social affiliation in zebrafish
Nunes, Ana Rita; Carreira, Leonor; Anbalagan, Savani; Blechman, Janna; Levkowitz, Gil; Oliveira, Rui FilipeSocial living animals need to recognize the presence of conspecifics in the environment in order to engage in adaptive social interactions. Social cues can be detected through different sensory modalities, including vision. Two main visual features can convey information about the presence of conspecifics: body form and biological motion (BM). Given the role that oxytocin plays in social behavior regulation acr...
Genetic variation in the social environment affects behavioral phenotypes of ox...
Ribeiro, Diogo; Nunes, Ana Rita; Teles, Magda C; Anbalagan, Savani; Blechman, Janna; Levkowitz, Gil; Oliveira, Rui FilipeOxytocin-like peptides have been implicated in the regulation of a wide range of social behaviors across taxa. On the other hand, the social environment, which is composed of conspecifics that may vary in their genotypes, also influences social behavior, creating the possibility for indirect genetic effects. Here, we used a zebrafish oxytocin receptor knockout line to investigate how the genotypic composition o...
Genetic variation in the social environment affects behavioral phenotypes of ox...
Ribeiro, Diogo; Nunes, Ana Rita; Teles, Magda C; Anbalagan, Savani; Blechman, Janna; Levkowitz, Gil; Oliveira, Rui FilipeOxytocin-like peptides have been implicated in the regulation of a wide range of social behaviors across taxa. On the other hand, the social environment, which is composed of conspecifics that may vary in their genotypes, also influences social behavior, creating the possibility for indirect genetic effects. Here, we used a zebrafish oxytocin receptor knockout line to investigate how the genotypic composition o...
Oxytocin receptor signaling modulates novelty recognition but not social prefer...
Ribeiro, Diogo; Nunes, Ana Rita; Gligsberg, Michael; Anbalagan, Savani; Levkowitz, Gil; Oliveira, RuiSociality is a complex phenomenon that involves the individual's motivation to approach their conspecifics, along with social cognitive functions that enable individuals to interact and survive. The nonapeptide oxytocin (OXT) is known to regulate sociality in many species. However, the role of OXT in specific aspects of sociality is still not well understood. In the present study we investigated the contributio...
Homeodomain protein Otp affects developmental neuropeptide switching in oxytoci...
Wircer, Einav; Blechman, Janna; Borodovsky, Nataliya; Tsoory, Michael; Nunes, Ana Rita; Oliveira, Rui Filipe; Levkowitz, GilProper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We show that developmental mutations in the zebrafish paralogous gene otpa but not otpb affect both stress response and social preference. These behavioral phenotypes we...
Homeodomain protein Otp affects developmental neuropeptide switching in oxytoci...
Wircer, Einav; Blechman, Janna; Borodovsky, Nataliya; Tsoory, Michael; Nunes, Ana Rita; Oliveira, Rui F; Levkowitz, GilProper response to stress and social stimuli depends on orchestrated development of hypothalamic neuronal circuits. Here we address the effects of the developmental transcription factor orthopedia (Otp) on hypothalamic development and function. We show that developmental mutations in the zebrafish paralogous gene otpa but not otpb affect both stress response and social preference. These behavioral phenotypes we...