8 documents found, page 1 of 1
Synthesis and pharmacological evaluation of pomalidomide derivatives useful for...
de Melo, Thais Regina Ferreira [UNESP]; Dulmovits, Brian; Fernandes, Guilherme Felipe dos Santos [UNESP]; de Souza, Cristiane M.; Lanaro, CarolinaMade available in DSpace on 2021-06-25T10:32:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Fetal hemoglobin (HbF) induction constitutes a valuable and validated approach to treat the symptoms of sickle cell disease (SCD). Here, we synthesized pomalidomide–nitric oxide (NO) donor derivatives (3a–f) and evaluated their suitability as novel HbF inducers. All compounds demonstrated different capa...
Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by hist...
Melo, Thais Regina Ferreira de [UNESP]; Kumkhaek, Chutima; Fernandes, Guilherme Felipe Dos Santos [UNESP]; Lopes Pires, Maria ElisaMade available in DSpace on 2018-12-11T17:37:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-25; N-oxide derivatives 5(a-b), 8(a-b), and 11(a-c) were designed, synthesized and evaluated in vitro and in vivo as potential drugs that are able to ameliorate sickle cell disease (SCD) symptoms. All of the compounds demonstrated the capacity to releasing nitric oxide at different levels ranging from 0.8 t...
Targeting Leishmania amazonensis amastigotes through macrophage internalisation...
Monteiro, Lis Marie; Löbenberg, Raimar; Ferreira, Elizabeth Igne; Cotrim, Paulo Cesar; Kanashiro, Edite; Rocha, Mussya; Chung, Man Chin [UNESP]Made available in DSpace on 2018-12-11T17:23:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-07-01; Dextran-coated poly (n-butyl cyanoacrylate) nanoparticles (PBCA-NPs) were prepared and were evaluated for enhanced delivery of a promising anti-Leishmania drug candidate, hydroxymethylnitrofurazone (NFOH), to phagocytic cells. Currently available chemotherapy for leishmaniasis, such as pentavalent antim...
Synthesis and biological activity of furoxan derivatives against Mycobacterium ...
Fernandes, Guilherme Felipe dos Santos [UNESP]; de Souza, Paula Carolina [UNESP]; Marino, Leonardo Biancolino [UNESP]; Chegaev, KonstantinMade available in DSpace on 2018-12-11T17:29:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Tuberculosis (TB) remains a serious health problem responsible to cause millions of deaths annually. The scenario becomes alarming when it is evaluated that the number of new drugs does not increase proportionally to the emergence of resista...
Pharmacological evaluation and preparation of nonsteroidal anti-inflammatory dr...
Melo, Thais Regina Ferreira de [UNESP]; Chelucci, Rafael Consolin [UNESP]; Pires, Maria Elisa Lopes [UNESP]; Dutra, Luiz Antonio [UNESP]Made available in DSpace on 2016-01-28T16:56:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2016-01-28T17:02:44Z : No. of bitstreams: 1 ISSN1422-0067-2014-15-04-5821-5837.pdf: 556278 bytes, checksum: b3ccb2d14d850126601995ebdd26a2bb (MD5); A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studie...
Anti-inflammatory drug design by molecular hybridization approach
Bosquesi, Priscila Longhin [UNESP]; Melo, Tais Regina Ferreira [UNESP]; Vizioli, Ednir de Oliveira [UNESP]; Santos, Jean Leandro dos [UNESP]Made available in DSpace on 2016-01-28T16:56:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2011. Added 1 bitstream(s) on 2016-01-28T17:02:43Z : No. of bitstreams: 1 ISSN1424-8247-2011-04-1450-1474.pdf: 805436 bytes, checksum: d04caf7bb2d3b8ffe958fd57cc0fce69 (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Pesquisa (CNPq); The design of new drugs with better phys...
Advances in drug design based on the amino acid approach: Taurine analogues for...
Chung, Man Chin [UNESP]; Malatesta, Pedro [UNESP]; Bosquesi, Priscila Longhin [UNESP]; Yamasaki, Paulo Renato [UNESP]; dos Santos, Jean Leandro [UNESP]Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:27:06Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:42:27Z : No. of bitstreams: 1 2-s2.0-84869206693.pdf: 345052 bytes, checksum: af1f663f5bb60b9d0121f6ed18b7e210 (MD5); Made available in DSpace on 2014-05-27T11:27:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-10-23; Amino acids are well known to be an...
Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Dr...
Ferreira de Melo, Thais Regina [UNESP]; Chelucci, Rafael Consolin [UNESP]; Lopes Pires, Maria Elisa [UNESP]; Dutra, Luiz Antonio [UNESP]Made available in DSpace on 2014-12-03T13:08:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-04-01Bitstream added on 2014-12-03T13:23:21Z : No. of bitstreams: 1 WOS000336841200042.pdf: 556278 bytes, checksum: b3ccb2d14d850126601995ebdd26a2bb (MD5); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a-e) were...