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Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2...

Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L.S.; Rosa, Maria Teresa; Mendes, Ana Catarina; Santos, Dulce; Nolasco, Sofia; Graca, Luis

Funding was also provided by Fundaci\u00F3n la Caixa through the project HR22-00741. Publisher Copyright: © The Author(s) 2025. Published by Oxford University Press on behalf of Society for Leukocyte Biology.; Toll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in nonmucosal dendritic cells (DCs) enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expres...


Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 ce...

Zúquete, Sara; Ferreira, Mariana; Delgado, Inês L.S.; Gazalle, Paula; Andaluz, Stephanie; Rosa, Maria Teresa; Mendes, Ana Catarina; Santos, Dulce

Funding Information: This work was funded by Fundação para a Ciência e a Tecnologia (FCT; Portugal) through the projects grants PTDC/CVT-CVT/31840/2017, PTDC/CVT-CVT/ 4599/2021, 2022.04903.PTDC, LA/P/0059/2020 (AL4AnimalS– Associate Laboratory for Animal and Veterinary Sciences), and UID/CVT/00276/2019 and UIDB/00276/2020 (CIISA– Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medi...


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