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Toxicological insights of Spike fragments SARS-CoV-2 by exposure environment: A...
Charlie-Silva, Ives; Araújo, Amanda P.C.; Guimarães, Abraão T.B.; Veras, Flávio P.; Braz, Helyson L.B.; de Pontes, Letícia G.; Jorge, Roberta J.B.Made available in DSpace on 2022-04-29T08:45:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-05; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The Spike protein (S protein) is a critical component in the infection of the new coronavirus (SARS-CoV-2). The objective of this work was to evaluate whether peptides fro...
Shedding light on toxicity of SARS-CoV-2 peptides in aquatic biota: A study inv...
Mendonça-Gomes, Juliana Moreira; Charlie-Silva, Ives; Guimarães, Abraão Tiago Batista; Estrela, Fernanda Neves; Calmon, Marilia Freitas [UNESP]Made available in DSpace on 2022-04-29T08:45:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-15; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Instituto Federal Goiás; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Knowledge about how the COVID-19 pandemic can affect aquatic wildlife is still extremely limited, and no effect of SARS-CoV-2 or its structural co...
Toxicological impact of SARS-CoV-2 on the health of the neotropical fish, Poeci...
Malafaia, Guilherme; Ahmed, Mohamed Ahmed Ibrahim; Souza, Sindoval Silva de; Rezende, Fernanda Neves Estrela; Freitas, Ítalo NascimentoMade available in DSpace on 2022-04-29T08:46:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-04-01; There have been significant impacts of the current COVID-19 pandemic on society including high health and economic costs. However, little is known about the potential ecological risks of this virus despite its presence in freshwater systems. In this study, we aimed to evaluate the exposure of Poecilia r...
Non-toxic dimeric peptides derived from the bothropstoxin-I are potent SARS-CoV...
Freire, Marjorie C. L. C.; Noske, Gabriela D.; Bitencourt, Natália V. [UNESP]; Sanches, Paulo R. S. [UNESP]; Santos-Filho, Norival A. [UNESP]Made available in DSpace on 2022-04-29T08:32:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-02; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health sy...
The Emergence of the New P.4 Lineage of SARS-CoV-2 With Spike L452R Mutation in...
Bittar, Cíntia [UNESP]; Possebon, Fábio Sossai [UNESP]; Ullmann, Leila Sabrina [UNESP]; Geraldini, Dayla Bott [UNESP]; da Costa, Vivaldo G. [UNESP]Made available in DSpace on 2022-04-29T08:35:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01; Financiadora de Estudos e Projetos; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Center for Information Technology; Center for Scientific Review; National Institutes of Health; Office of Extramural Research, National...
Antimicrobial Peptide K0-W6-Hya1 Induces Stable Structurally Modified Lipid Dom...
Enoki, Thais A.; Moreira-Silva, Isabela; Lorenzon, Esteban N.; Cilli, Eduardo M. [UNESP]; Perez, Katia R.; Riske, Karin A.; Lamy, M. TeresaMade available in DSpace on 2022-04-30T05:16:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-02-06; Considering the known different mode of action of antimicrobial peptides in zwitterionic and anionic cell membranes, the present work compares the action of the antimicrobial peptide K0-W6-Hya1 (KIFGAIWPLALGALKNLIK-NH2) with zwitterionic and negatively charged model membranes, namely, liposomes composed...
Nanostructured functional peptide films and their application in C-reactive pro...
Piccoli, Julia P.; Soares, Andrey C.; Oliveira, Osvaldo N.; Cilli, Eduardo M. [UNESP]Made available in DSpace on 2022-05-01T02:37:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01; Peptides with an active redox molecule are incorporated into nanostructured films for electrochemical biosensors with stable and controllable physicochemical properties. In this study, we synthesized three ferrocene (Fc)-containing peptides with the sequence Fc-Glu-(Ala)n-Cys-NH2, which could form self-...
Recent advances in SARS-CoV-2 Spike protein and RBD mutations comparison betwee...
Sanches, Paulo R.S. [UNESP]; Charlie-Silva, Ives; Braz, Helyson L.B.; Bittar, Cíntia [UNESP]; Freitas Calmon, Marilia [UNESP]; Rahal, Paula [UNESP]Made available in DSpace on 2022-05-01T09:30:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); New variants of SARS-CoV-2 Alpha (B.1.1.7); Beta (B.1.351) Gamma (P.1) and Delta (B.1.617.2) quickly spread in the UK, South Africa, Brazil and India, respectively. To address whether mutations in SARS-CoV-2 RBD spike protein could affect vi...
What different physical techniques can disclose about disruptions on membrane s...
Vignoli Muniz, Gabriel S.; Duarte, Evandro L.; Lorenzón, Esteban N.; Cilli, Eduardo M. [UNESP]; Lamy, M. TeresaMade available in DSpace on 2022-05-01T12:25:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01; The present work monitors structural changes in anionic membranes (DPPG; 1,2-dipalmitoyl-sn-glycero-3-phospho-(1′-rac-glycerol)) caused by the native antimicrobial peptide (AMP) Hylin a1 (Hya1; IFGAILPLALGALKNLIK-NH2) and its synthetic analogue K0Hya1 (KIFGAILPLALGALKNLIK-NH2), with an extra positive re...
Hesperetin targets the hydrophobic pocket of the nucleoprotein/phosphoprotein b...
Sá, Jéssica M. [UNESP]; Piloto, João V. [UNESP]; Cilli, Eduardo M. [UNESP]; Tasic, Ljubica; Fossey, Marcelo A. [UNESP]; Almeida, Fábio C. L.Made available in DSpace on 2021-06-25T10:36:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01; The human Respiratory Syncytial Virus (hRSV) is one of the most common causes of acute respiratory diseases such as bronchiolitis and pneumonia in children worldwide. Among the viral proteins, the nucleoprotein (N) stands out for forming the nucleocapsid (NC) that functions as a template for replication...