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Cytocompatibility and Synergy of EGCG and Cationic Peptides Against Bacteria Re...
Caiaffa, Karina Sampaio [UNESP]; dos Santos, Vanessa Rodrigues [UNESP]; Abuna, Gabriel Flores; Santos-Filho, Norival Alves [UNESP]Made available in DSpace on 2022-04-29T08:31:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; This study evaluated the cytocompatibility and antimicrobial/antibiofilm effects of epigallocatechin-3-gallate (EGCG) associated with peptide LL-37 and its analogue KR-12-a5 against oral pathogens. The effect of the compounds on metabolism of fibroblasts was evaluated by methyltetrazolium assays. Antimi...
Insights on the inhibition properties of Jatromollistatin (a cyclic heptapeptid...
Jucá, Thiago Lustosa; Ramos, Márcio Viana; Cilli, Eduardo Maffud [UNESP]; Neto, Antônio Eufrásio Vieira; Mackessy, Stephen P.Made available in DSpace on 2022-04-29T08:40:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Jatropha mollissima is endemic to Brazil and is used for traditional medicinal purposes, including the treatment of snakebite. In this study, latex obtained from this plant was fractioned using reversed-phase chromatography, and the fractions were then screened for peptides. A 755 g/mol peptide was obta...
Biophysical Studies of TOAC Analogs of the Ctx(Ile21)-Ha Antimicrobial Peptide ...
Vicente, Eduardo Festozo [UNESP]; Basso, Luis G. M.; Crusca Junior, Edson [UNESP]; Roque-Borda, Cesar A. [UNESP]; Costa-Filho, Antonio J.Made available in DSpace on 2022-04-29T08:40:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-06-01; Antimicrobial peptides (AMP) are innate components of the defense system of many forms of life, composing the first line of defense from invading pathogens. Among many AMPs described in several databases, the Ctx(Ile21)-Ha antimicrobial peptide has been proven as a very promising molecule for applicatio...
Effect of C-terminal and N-terminal dimerization and alanine scanning on antiba...
Santos-Filho, Norival Alves [UNESP]; Righetto, Gabriela Marinho; Pereira, Marina Rodrigues [UNESP]; Piccoli, Julia Pinto [UNESP]Made available in DSpace on 2022-05-01T09:00:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); The peptide (p-BthTX-I)2 [(KKYRYHLKPFCKK)2] and its analog des-Lys12,Lys13-(p-BthTX-I)2 [(KKYRYHLKPFC)2] showed activity against bacteria and potential specificity against...
PyrGF and GSTLN peptides enhance pravastatin's inhibition of 3-hydroxy-3-methyl...
da Silva, Jaff Ribeiro [UNESP]; de Cerqueira e Silva, Mariana Barros [UNESP]; Philadelpho, Biane Oliveira; de Souza, Victória CruzMade available in DSpace on 2022-05-01T10:35:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado da Bahia; Two newly designed peptides, Pyr-GF and GSTLN, enhan...
Uso da FTIR na obtenção de resinas e na síntese de peptídeos em fase sólida
Cespedes, Graziely Ferreira [UNESP]; Vicente, Eduardo Festozo [UNESP]; Cilli, Eduardo Maffud [UNESP]; Jubilut, Guita Nicolaewsky; Nakaie, Clovis RyuichiMade available in DSpace on 2022-04-28T22:37:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-06-06; Despite the increase in peptide chain aggregation, which decreases the rate of coupling reactions, the synthesis and use of very highly substituted resins still remains as a controversial point in the SPPS, due to its clear economical advantages (lesser solvent consumption and higher amount of peptide p...
Amino acid, antioxidant and ion profiles of carpolobia lutea leaf (Polygalaceae)
Nwidu, Lucky Legbosi; Cilli, Eduardo Maffud [UNESP]; Vilegas, Wagner [UNESP]Made available in DSpace on 2022-04-29T05:37:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-10-01; Purpose: To evaluate the amino acid, antioxidant and ionic profiles of Carpolobia lutea leaf (Polygalaceae) extract (CLL). Methods: The powdered leaf was macerated and subjected to gradient solvent extraction with nhexane, chloroform, ethyl acetate and ethanol for 72 h to obtain their respective fractio...
Haematological, biochemical and immunological biomarkers, antibacterial activit...
de Sousa, Elielma Lima [UNESP]; Assane, Inácio Mateus [UNESP]; Santos-Filho, Norival Alves [UNESP]; Cilli, Eduardo Maffud [UNESP]Made available in DSpace on 2021-06-25T10:45:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-25; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Among the antimicrobial peptides (AMPs), which act as natural antibiotics in preventing the colonization of pathogens, LL-37 is noteworthy. It is a human cathelicidin characterized as a broad-spectrum antibiotic, with chemotactic and immunom...
Understanding the mechanism of action of peptide (p-BthTX-I)2 derived from C-te...
Santos-Filho, Norival Alves [UNESP]; de Freitas, Laura Marise [UNESP]; Santos, Claudia Tavares dos [UNESP]; Piccoli, Julia Pinto [UNESP]Made available in DSpace on 2021-06-25T10:57:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Based on the antimicrobial activity of bothropstoxin-I (BthTX-I) and on the premise that a C-terminal ...
In vivo effectiveness of hybrid membranes with osteogenic growth peptide for bo...
Oshiro-Junior, João Augusto [UNESP]; Barros, Rafaela Moreno; da Silva, Camila Garcia [UNESP]; de Souza, Caroline Cordeiro [UNESP]Made available in DSpace on 2021-06-25T11:01:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Guided bone regeneration (GBR) technique helps to restore bone tissue through cellular selectivity principle. Currently no osteoinductive membrane exists on the market. Osteogenic growth peptide (OGP) acts as a hematopoietic stimulator. This association could improve the quality of bone formation, benef...