4 documents found, page 1 of 1
Acute physical exercise increases leptin-induced hypothalamic extracellular sig...
Gaspar, Rafael Calais, 1992-; Muñoz, Vitor Rosetto, 1993-; Nakandakari, Susana Castelo Branco Ramos; Minuzzi, Luciele Guerra; Botezelli, José DiegoAgradecimentos: The authors thank Obesity and Comorbidities Research Center – OCRC and FAPESP (2016/18488-8) and CNPq (306535/2017-3) for all support during the experiment; The obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypotha...
TGF-ß1 downregulation in the hypothalamus of obese mice through acute exercise
Silva, Vagner Ramon Rodrigues, 1985-; Lenhare, Luciene, 1984-; Katashima, Carlos Kiyoshi, 1976-; Morari, Joseane, 1982-Agradecimentos: We thank the São Paulo Foundation Research (FAPESP), Coordination for the Improvement of Higher Education Personnel (CAPES) and Obesity and Comorbidities Research Center (OCRC) for technical and financial support; Abstract: Obesity and aging lead to abnormal transforming growth factor-ß1 (TGF-ß1) signaling in the hypothalamus, triggering the imbalance on glucose metabolism and energy homeostasis...
Mechanisms in endocrinology : hypothalamic inflammation and nutrition
Araujo, Eliana Pereira de, 1965-; Garotti, Juliana Contin Moraes; Cintra, Dennys Esper, 1976-; Velloso, Licio Augusto, 1963-Abstract: Selected subpopulations of hypothalamic neurons play important roles in the regulation of whole body energy homeostasis. Studies have shown that the saturated fats present in large amounts in western diets can activate an inflammatory response in the hypothalamus, affecting the capacity of such neurons to respond appropriately to satiety and adipostatic signals. In the first part of this review, we wi...
Integração entre vias metabolicas e inflamatorias durante a esteatose hepatica ...
Cintra, Dennys Esper, 1976-Orientador: Licio Augusto Velloso; Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas; Resumo: A obesidade se manifesta de forma pandêmica, acometendo milhões de pessoas, principalmente nos países ocidentais e industrializados. Além dos inúmeros aspectos comportamentais e sociais, o desenvolvimento dessa doença contribui consideravelmente para o aumento da morbidade e mortalidad...