2 documents found, page 1 of 1
Roadmap on nanomedicine for the central nervous system
Ciofani, Gianni; Campisi, Marco; Mattu, Clara; Kamm, Roger D.; Chiono, Valeria; Raynold, Aji Alex Moothedathu; Freitas, João S.; Redolfi Riva, EugenioIn recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the stat...
Boron nitride nanotube-mediated stimulation of cell co-culture on micro-enginee...
Ricotti, Leonardo; Fujie, Toshinori; Vazão, Helena; Ciofani, Gianni; Marotta, Roberto; Brescia, Rosaria; Filippeschi, Carlo; Corradini, IreneIn this paper, we describe the effects of the combination of topographical, mechanical, chemical and intracellular electrical stimuli on a co-culture of fibroblasts and skeletal muscle cells. The co-culture was anisotropically grown onto an engineered micro-grooved (10 µm-wide grooves) polyacrylamide substrate, showing a precisely tuned Young's modulus (∼ 14 kPa) and a small thickness (∼ 12 µm). We enhanced the...