22 documents found, page 1 of 3
Tumor Stroma Area and Other Prognostic Factors in Pancreatic Ductal Adenocarcin...
Amaral, Maria João; Amaral, Mariana; Freitas, João; Oliveira, Rui Caetano; Serôdio, Marco; Cipriano, Maria Augusta; Tralhão, José GuilhermePancreatic ductal adenocarcinoma (PDAC) has a dense stroma, responsible for up to 80% of its volume. The amount of stroma can be associated with prognosis, although there are discrepancies regarding its concrete impact. The aim of this work was to study prognostic factors for PDAC patients submitted to surgery, including the prognostic impact of the tumor stroma area (TSA). A retrospective study with PDAC patie...
IgG4-Related Esophageal Disease Presenting as Esophagitis with Chronic Strictures
Correia, Catarina; Moreira, Hélder; Almeida, Nuno; Soares, Marta; Cipriano, Maria Augusta; Figueiredo, PedroIgG4-related disease is a recently recognized autoimmune systemic disorder that has been described in various organs. The disease is characterized histologically by a dense lymphoplasmacytic infiltrate with IgG4-positive cells, storiform fibrosis, obliterative phlebitis, and can be associated with space-occupying lesions. IgG4-related disease involving the upper gastrointestinal tract is rare. We report the cas...
Innate Immune Cells in the Tumor Microenvironment of Liver Metastasis from Colo...
Sampaio-Ribeiro, Gabriela; Ruivo, Ana; Silva, Ana; Santos, Ana Lúcia; Oliveira, Rui Caetano; Gama, João; Cipriano, Maria AugustaColorectal cancer (CRC) is the third most prevalent type of cancer, and liver metastasis is the most common site of metastatic development. In the tumor microenvironment (TME), various innate immune cells are known to influence cancer progression and metastasis occurrence. CD274 (PD-L1) and CD206 (MRC1) are proteins that have been associated with poor prognosis and disease progression. We conducted a study on t...
Concomitant Nitrofurantoin-Induced Autoimmune Hepatitis and Interstitial Lung D...
Matos, Andreia Carvalho de; Macedo, Cristiane Pais; Mendes, Patrícia Afonso; Cipriano, Maria Augusta; Paiva, Artur; Simão, AdéliaAntibiotics are known to cause adverse reactions, but multiple organ involvement associated with nonspecific symptoms can lead to a delay in diagnosis. A definitive correlation between each toxin and its effects is difficult to establish due to concomitant potential toxins in the circulation. This article highlights an uncommon case of concomitant nitrofurantoin- induced autoimmune hepatitis and lung fibrosis t...
Histological scores and tumor size on stage II in adrenocortical carcinomas
Oliveira, Rui Caetano de; Martins, Maria João; Moreno, Carolina; Almeida, Rui; Carvalho, João; Teixeira, Paulo; Teixeira, Miguel; Silva, Edgar TavaresAdrenocortical carcinomas (ACC) are aggressive tumors with a poor prognosis. Histological scores are advised for the diagnosis, however, there are borderline cases that may be misjudged as adrenocortical adenomas (ACA). The three main scores used are: Weiss Modified System (WMS), Reticulin Algorithm (RA), and Helsinki Score (HS). We intend to compare the accuracy of the three scores in ACC diagnosis and to iden...
De novo colorectal cancer after liver and kidney transplantation–Microenvironme...
Oliveira, Rui Caetano; Silva, Edgar Tavares da; Abrantes, Ana Margarida; Antunes, Hugo; Teixeira, Paulo; Gomes, Ana; Martins, Ricardo; Furtado, EmanuelColorectal cancer (CRC) is a major health burden and may arise as a complication of solid organ transplantation. Our study aimed to assess the incidence of the CRC in kidney and liver transplanted patients at a tertiary and reference center and to describe their clinical and pathological features. Twelve patients, 10 men and two women, with a mean age of 60 years, composed our cohort, ten of them submitted to C...
Prognostic Factors After Hepatectomy for Gastric Adenocarcinoma Liver Metastase...
Temido, Maria José; Oliveira, Rui Caetano; Martins, Ricardo; Serôdio, Marco; Costa, Beatriz; Carvalho, César; Santos, Eva; Ferreira, LuísPurpose: Hepatectomy (Hp) is an alternative approach for the treatment of gastric carcinoma liver metastases (GCLM). However, prognostic factors that may assist patient selection are still controversial. Several pathologic features, such as the growth pattern (GP), associated with prognosis in colorectal cancer liver metastases, were never investigated in GCLM. Our principal aim was to assess if the GP has prog...
Intraductal Papillary Mucinous Neoplasia of the Pancreas - Pathologic Features ...
Cipriano, Maria Augusta; Oliveira, Rui CaetanoIntraductal papillary mucinous neoplasm (IPMN) of the pancreas are pre neoplastic lesions defined by the World Health Organization as a grossly visible intraductal epithelial neoplasm that arises in the pancreatic ductal system, composed of mucin producing cells. The predisposing factor for their development as well as genetics are still largely unknown. Pathologists have a pivotal role in IPMN management since...
Neuroendocrine Carcinoma and Intracystic Papillary Neoplasm: A Rare Association...
Fraga, João; Caetano Oliveira, Rui; Alexandrino, Henrique; Cipriano, Maria AugustaNeuroendocrine carcinoma of the gallbladder is a very rare neoplasia comprising only 0.2% of all the gastrointestinal neuroendocrine tumors. We present the case of an 85-year-old male with nonspecific gastrointestinal symptoms, progressive weight loss, and deterioration in the preceding 15 days. Imaging study showed a 5-cm polypoid mass localized at the gallbladder fundus, leading to a radical cholecystectomy. ...
Liver Metastases and Histological Growth Patterns: Biological Behavior and Pote...
Oliveira, Rui Caetano; Alexandrino, Henrique; Cipriano, Maria Augusta; Tralhão, José GuilhermeColorectal cancer is a major health burden and despite the recent advances in healthcare and screening programs, a great percentage of patients already present metastases once their disease is found. In those cases, liver surgery has an essential role, but even with neoadjuvant chemotherapy there is a high rate of intrahepatic recurrence. New prognostic factors are needed in order to decide the best surgical ap...