3 documents found, page 1 of 1
Differential production of type I IFN determines the reciprocal levels of IL-10...
Howes, Ashleigh; Taubert, Christina; Blankley, Simon; Spink, Natasha; Wu, Xuemei; Graham, Christine M.; Zhao, Jiawen; Saraiva, MargaridaPattern recognition receptors detect microbial products and induce cytokines, which shape the immunological response. IL-12, TNF-alpha, and IL-1 beta are proinflammatory cytokines, which are essential for resistance against infection, but when produced at high levels they may contribute to immunopathology. In contrast, IL-10 is an immunosuppressive cytokine, which dampens proinflammatory responses, but it can a...
Type I IFN inhibits alternative macrophage activation during mycobacterium tube...
Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; McNab, Finlay W.; Torrado, Egídio; Cardoso, Filipa; Machado, Henrique; Castro, FláviaSupplementary material: http://www.jimmunol.org/content/suppl/2016/11/12/jimmunol.1600584.DCSupplemental; Tuberculosis causes ∼1.5 million deaths every year, thus remaining a leading cause of death from infectious diseases in the world. A growing body of evidence demonstrates that type I IFN plays a detrimental role in tuberculosis pathogenesis, likely by interfering with IFN-γ–dependent immunity. In this artic...
TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial...
McNab, Finlay W.; Ewbank, John; Rajsbaum, Ricardo; Stavropoulos, Evangelos; Martirosyan, Anna; Redford, Paul S.; Wu, Xuemei; Graham, Christine M.Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of mortality and morbidity worldwide, causing ~1.4 million deaths per year. Key immune components for host protection during tuberculosis include the cytokines IL-12, IL-1, and TNF-a, as well as IFN-? and CD4(+) Th1 cells. However, immune factors determining whether individuals control infection or progress to active tuberculosis are in...