6 documents found, page 1 of 1
Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes ...
Rodrigues, Matilde S.; Ferreira, Samira G.; Quiroz, César; Earley, Christopher J; García-Borreguero, Diego; Cunha, Rodrigo A.; Ciruela, FranciscoBrain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS, since it recapitulates key neurochemical changes reported in RLS patients and shows an RLS-like behavioral phenotype. Previous studies with the BID-rodent model of RLS demonstrated increased sensitivity of cortical pyramidal cells to relea...
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, RamónIt has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved in the modulation of striatal excitatory neurotransmission. Previous studies have demonstrated the existence of A2AR-CB1R heteromers in artificial cell systems. A dependence of A2AR s...
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, RamónBackground: It has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved in the modulation of striatal excitatory neurotransmission. Previous studies have demonstrated the existence of A2AR-CB1R heteromers in artificial cell systems. A dependen...
G protein-coupled receptor 37 (GPR37) emerges as an important modulator of aden...
Morato, Xavier; Cunha, Rodrigo A.; Ciruela, FranciscoThis work was supported by Fondo Europeo de Desarrollo Regional (FEDER)/Ministerio de Ciencia, Innovación y Universidades– Agencia Estatal de Investigación (SAF2017-87349-R) and Instituto de Salud Carlos III (ISCIII) (PIE14/00034), the Catalan government (2017 SGR 1604), Fundació la Marató de TV3 (Grant 20152031), Fonds Wetenschappelijk Onderzoek (FWO) (SBO- 140028) to FC and Centro 2020 (projects CENTRO-01-014...
The Parkinson's disease-associated GPR37 receptor interacts with striatal adeno...
Morató, Xavier; Luján, Rafael; López-Cano, Marc; Gandía, Jorge; Stagljar, Igor; Watanabe, Masahiko; Cunha, Rodrigo A.; Fernández-Dueñas, VíctorG protein-coupled receptor 37 (GPR37) is an orphan receptor associated to Parkinson's disease (PD) neuropathology. Here, we identified GPR37 as an inhibitor of adenosine A2A receptor (A2AR) cell surface expression and function in vivo. In addition, we showed that GPR37 and A2AR do oligomerize in the striatum. Thus, a close proximity of GPR37 and A2AR at the postsynaptic level of striatal synapses was observed b...
Adenosine receptor heteromers and their integrative role in striatal function
Ferré, Sergi; Ciruela, Francisco; Quiroz, César; Luján, Rafael; Popoli, Patrizia; Cunha, Rodrigo A.; Agnati, Luigi F; Fuxe, Kjell; Woods, Amina SBy analyzing the functional role of adenosine receptor heteromers, we review a series of new concepts that should modify our classical views of neurotransmission in the central nervous system (CNS). Neurotransmitter receptors cannot be considered as single functional units anymore. Heteromerization of neurotransmitter receptors confers functional entities that possess different biochemical characteristics with ...