6 documents found, page 1 of 1
Loss of 5 '-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade ...
Menezes, Weder Pereira de; Oliveira Silva, Viviane Aline; Faria Gomes, Izabela Natalia; Rosa, Marcela Nunes; Corcoll Spina, Maria LuisaMade available in DSpace on 2020-12-10T19:54:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-02-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Barretos Cancer Hospital; Public Ministry of Labor Campinas (Research, Prevention and Education of Occ...
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Gonçalves, Céline S.; Castro, Joana Isabel Martins Cosme Vieira; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro Filipe Monteiro; Chautard, EmmanuelGlioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were...
Study of hTERT and Histone 3 Mutations in Medulloblastoma
Pereira, Marta Sofia Carvalho Ribeiro Viana; Almeida, Gisele Caravina; Stavale, João Norberto; Malheiro, Susana; Clara, Carlos; Lobo, PatríciaHotspot activating mutations of the telomerase reverse transcriptase (hTERT) promoter region were recently described in several tumor types. These mutations lead to enhanced expression of telomerase, being responsible for telomere maintenance and allowing continuous cell division. Additionally, there are alternative telomere maintenance mechanisms, associated with histone H3 mutations, responsible for disruptin...
KIAA1549: BRAF gene fusion and FGFR1 hotspot mutations are prognostic factors i...
Becker, Aline Paixão; Scapulatempo-Neto, Cristovam; Carloni, Adriana C.; Paulino, Alessandra; Sheren, Jamie; Aisner, Dara L.; Musselwhite, EvelynUp to 20% of patients with pilocytic astrocytoma (PA) experience a poor outcome. BRAF alterations and Fibroblast growth factor receptor 1 (FGFR1) point mutations are key molecular alterations in Pas, but their clinical implications are not established. We aimed to determine the frequency and prognostic role of these alterations in a cohort of 69 patients with PAs. We assessed KIAA1549:BRAF fusion by fluorescenc...
Expression of methylthioadenosine phosphorylase (MTAP) in pilocytic astrocytomas
Becker, Aline Paixão; Scapulatempo-Neto, Cristovam; Menezes, Weder P.; Clara, Carlos; Machado, Hélio R.; Oliveira, Ricardo S.; Neder, LucianoBACKGROUND/OBJECTIVES Pilocytic astrocytomas (PAs) are the most frequent astrocytomas in children and adolescents. Methilthioadenosine phosphorylase(MTAP) is a tumor-suppressor gene, the loss of expression of which is associated with a poor prognosis and better response to specific chemotherapy in leukemia and non-small-cell lung cancer. The expression of MTAP in brain tumors remains largely unknown and its bio...
In vitro and in vivo analysis of RTK inhibitor efficacy and identification of i...
Martinho, Olga; Oliveira, Renato José Silva; Gonçalves, Vera M.; Clara, Carlos; Almeida, José Reynaldo; Carvalho, André Lopes; Barata, João TabordaTreatment for glioblastoma consists of radiotherapy and temozolomide-based chemotherapy. However, virtually all patients recur, leading to a fatal outcome. Receptor tyrosine kinase (RTK)-targeted therapy has been the focus of attention in novel treatment options for these patients. Here, we compared the efficacy of imatinib, sunitinib, and cediranib in glioblastoma models. In the present work, the biologic effe...