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Surgical Options After Fontan Failure

van Melle, JP; Wolff, D; Hörer, J; Belli, E; Meyns, B; Padalino, M; Lindberg, H; Jacobs, J; Mattila, I; Berggren, H; Berger, R; Prêtre, R; Hazekamp, M

OBJECTIVE: The objective of this European multicenter study was to report surgical outcomes of Fontan takedown, Fontan conversion and heart transplantation (HTX) for failing Fontan patients in terms of all-cause mortality and (re-)HTX. METHODS: A retrospective international study was conducted by the European Congenital Heart Surgeons Association among 22 member centres. Outcome of surgery to address failing Fo...


Intravenous Busulfan for Autologous Stem Cell Transplantation in Adult Patients...

Nagler, A; Labopin, M; Gorin, NC; Ferrara, F; Sanz, M; Wu, D; Gomez, A; Lapusan, S; Irrera, G; Guimaraes, J; Botelho de Sousa, A; Carella, A; Vey, N

Oral busulfan is the historical backbone of the busulfan+cyclophosphamide regimen for autologous stem cell transplantation. However intravenous busulfan has more predictable pharmacokinetics and less toxicity than oral busulfan; we, therefore, retrospectively analyzed data from 952 patients with acute myeloid leukemia who received intravenous busulfan for autologous stem cell transplantation. Most patients were...


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