2 documents found, page 1 of 1
Emergence of Multidrug-Resistant Mycobacterium Tuberculosis of the Beijing Line...
Perdigão, J; Silva, C; Maltez, F; Machado, D; Miranda, A; Couto, I; Rabna, P; Florez de Sessions, P; Phelan, J; Pain, A; McNerney, R; Hibberd, MThe Beijing genotype comprises a highly disseminated strain type that is frequently associated with multidrug resistant (MDR) tuberculosis (TB) and increased transmissibility but, countries such as Portugal and Guinea-Bissau fall outside the regions phylogeographically associated with this specific genotype. Nevertheless, recent data shows that this genotype might be gradually emerging in these two countries as...
Using Genomics to Understand the Origin and Dispersion of Multidrug and Extensi...
Perdigão, J; Gomes, P; Miranda, A; Maltez, F; Machado, D; Silva, C; Phelan, J; Brum, L; Campino, S; Couto, I; Viveiros, M; Clark, T; Portugal, IPortugal is a low incidence country for tuberculosis (TB) disease. Now figuring among TB low incidence countries, it has since the 1990s reported multidrug resistant and extensively drug resistant (XDR) TB cases, driven predominantly by two strain-types: Lisboa3 and Q1. This study describes the largest characterization of the evolutionary trajectory of M/XDR-TB strains in Portugal, spanning a time-period of two...