4 documents found, page 1 of 1
New insights into how cancer cells regulate glucose uptake by protein phosphory...
Henriques, Andreia; Matos, Paulo; Clarke, Luka; Jordan, PeterCancer cells require increased amounts of glucose to sustain their proliferation and upregulate plasma membrane expression of glucose transporter GLUT1. In insulin responsive cells, glucose uptake requires previous phosphorylation of TBC1D4, a negative regulator of endosomal GLUT traffic. Previous work published by the host lab has discovered that protein kinase WNK1 can also phosphorylate TBC1D4 and promote th...
Molecular regulation of the plasma membrane retention of disease-related chlori...
Loureiro, Claudia; Matos, P; Clarke, Luka; Jordan, PeterThree disease-related chloride transport proteins, CFTR (in cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD)), NKCC2 and KCC3 (in kidney function and hypertension), were found to specific targets for protein kinase Syk which phosphorylates a specific tyrosine residue in each channel. Tyrosine phosphorylation downregulates the amount of CFTR [1] present at the plasma membrane and a better und...
The adaptor protein SHC1 is recruited to tyrosine-phosphorylated plasma membran...
Loureiro, Claudia; Matos, Paulo; Clarke, Luka; Jordan, PeterProtein kinase Syk was recently found to phosphorylate a specific tyrosine residue in three distinct disease-related chloride transport proteins: CFTR (in cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD)), NKCC2 and KCC3 (in kidney function and hypertension).
Regulation of Glucose uptake in mammalian cells by phosphorylation networks
Henriques, Andreia; Jordan, Peter; Clarke, LukaObjectives: Characterize the role of protein kinase WNK1 in the phosphorylation network regulating cellular glucose uptake