4 documents found, page 1 of 1
Which imaging outcomes for axSpA are most sensitive to change?
Sepriano, Alexandre; Ramiro, Sofia; van der Heijde, Désirée; Dougados, Maxime; Claudepierre, Pascal; Feydy, Antoine; Reijnierse, MoniqueOBJECTIVE: To compare the sensitivity to change of different imaging scoring methods in patients with early axial spondyloarthritis (axSpA). METHODS: Patients from the DESIR cohort fulfilling the ASAS axSpA criteria were included. Radiographs and MRI of the sacroiliac joints (SIJ) and spine were obtained at baseline, 1, 2 and 5 years. Each image was scored by 2 or 3 readers in 3 separate 'reading-waves'. The ra...
Inflammation of the sacroiliac joints and spine on MRI predicts structural chan...
Sepriano, Alexandre; Ramiro, Sofia; Landewé, Robert; Moltó, Anna; Claudepierre, Pascal; Wendling, Daniel; Dougados, Maxime; van der Heijde, DésiréeThis article is protected by copyright. All rights reserved.; OBJECTIVE: To test the impact of inflammation on MRI-structural changes occurring in the sacroiliac joints (SIJ) and the spine. METHODS: Patients with early axSpA from the DESIR cohort were included. MRIs of the SIJ (MRI-SIJ) and spine (MRI-spine), obtained at baseline, 2 and 5 years, were scored by 3 central readers. Inflammation and structural dama...
5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spon...
Madari, Queeny; Sepriano, Alexandre; Ramiro, Sofia; Molto, Anna; Claudepierre, Pascal; Wendling, Daniel; Dougados, Maxime; Van Der Heijde, DesiréeFunding: g Devenir des Spondyloarthropathies Indifférenciées Récentes (DESIR) is financially supported by an unrestricted grant from Pfizer. AS is supported by a doctoral grant from 'Fundação para a Ciência e Tecnologia' (SFRH/ BD/108246/2015). The DESIR study is conducted as a Programme Hospitalier de Recherche Clinique with Assistance Publique Hopitaux de Paris as the sponsor. The DESIR study is also under th...
Spinal Radiographic Progression in Early Axial Spondyloarthritis
Ramiro, Sofia; van der Heijde, Désirée; Sepriano, Alexandre; van Lunteren, Miranda; Moltó, Anna; Feydy, Antoine; d'Agostino, Maria AntoniettaObjective: To analyze the progression of spinal radiographic damage in patients with early axial spondyloarthritis (SpA). Methods: Axial SpA patients from the DESIR (Devenir des Spondylarthropathies Indifférenciées Récentes) cohort with 5-year spinal (cervical and lumbar) radiographs available (n = 549) were included. Two- and 5-year modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) progression and dev...