3 documents found, page 1 of 1
β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis
Silva, AM; Chan, FY; Norman, MJ; Sobral, AF; Zanin, E; Gassmann, R; Belmonte, JM; Carvalho, AXCytokinesis requires the constriction of an actomyosin-based contractile ring and involves multiple F-actin crosslinkers. We show that partial depletion of the C. elegans cytokinetic formin generates contractile rings with low F-actin levels that constrict but are structurally fragile, and we use this background to investigate the roles of the crosslinkers plastin/PLST-1 and β-heavy-spectrin/SMA-1 during ring c...
Equatorial Non-muscle Myosin II and Plastin Cooperate to Align and Compact F-ac...
Leite, J; Chan, FY; Osório, DS; Saramago, J; Sobral, AF; Silva, AM; Gassmann, R; Carvalho, AXCytokinesis is the last step of cell division that physically partitions the mother cell into two daughter cells. Cytokinesis requires the assembly and constriction of a contractile ring, a circumferential array of filamentous actin (F-actin), non-muscle myosin II motors (myosin), and actin-binding proteins that forms at the cell equator. Cytokinesis is accompanied by long-range cortical flows from regions of r...
Network contractility during cytokinesis-from molecular to global views
Leite, J; Osório, DS; Sobral, AF; Silva, AM; Carvalho, AXCytokinesis is the last stage of cell division, which partitions the mother cell into two daughter cells. It requires the assembly and constriction of a contractile ring that consists of a filamentous contractile network of actin and myosin. Network contractility depends on network architecture, level of connectivity and myosin motor activity, but how exactly is the contractile ring network organized or interco...