3 documents found, page 1 of 1
Síntese de novas amidas graxas a partir da aminólise de ésteres metílicos
Lopes,Carolina R.; D'Oca,Caroline Da Ros Montes; Duarte,Rodrigo da C.; Kurz,Márcia H. S.; Primel,Ednei G.; Clementin,Rosilene M.Recent biochemical and pharmacological studies have led to the characterization of different fatty acid amides as a new family of biologically active lipids. Here, we describe the synthesis of new amides from C16:0, 18:0, 18:1 and 18:1, OH fatty acids (FFA) families with cyclic and acyclic amines and demonstrate for the first time that these compounds produce citotoxic effects. Application of this method to the...
Development and validation of a method using SPE and LC-ESI-MS-MS for the deter...
Demoliner,Adriana; Caldas,Sergiane S.; Costa,Fabiane P.; Gonçalves,Fábio F.; Clementin,Rosilene M.; Milani,Márcio R.; Primel,Ednei G.An analytical method using solid-phase extraction and liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS-MS) was developed and validated for the determination and confirmation of eighteen polar pesticides (herbicides, insecticides and fungicides) and two metabolites in water samples. The limits of detection varied between 0.4-40.0 ng L-1 and the limits of quantification...
Reações intramoleculares como modelos não miméticos de catálise enzimática
Gesser,José Carlos; Yunes,Santiago; Clementin,Rosilene M.; Nome,FarukThis review gives a critical idea on the importance of intramolecular reactions as models for enzymatic catalysis. Intramolecular lactonizations, ester and amide hydrolysis studies result in theories which try to explain the difference between intermolecular, intramolecular and enzyme reactions and rationalize the enhancement promoted by these biological catalyst.