2 documents found, page 1 of 1
Global Impact of COVID-19 on Stroke Care and IV Thrombolysis
Nogueira, RG; Qureshi, MM; Abdalkader, M; Martins, SO; Yamagami, H; Qiu, Z; Mansour, OY; Sathya, A; Czlonkowska, A; Tsivgoulis, G; Aguiar de Sousa, DObjective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified ...
Hierarchical structured and programmed vehicles deliver drugs locally to inflam...
Li, W; Li, Y; Liu, Z; Kerdsakundee, N; Zhang, M; Zhang, F; Liu, X; Bauleth-Ramos, T; Lian, W; Mäkilä, E; Kemell, M; Ding, Y; Sarmento, BOrally administrable drug delivery vehicles are developed to manage incurable inflammatory bowel disease (IBD), however, their therapeutic outcomes are compromised by the side effects of systemic drug exposure. Herein, we use hyaluronic acid functionalized porous silicon nanoparticle to bridge enzyme-responsive hydrogel and pH-responsive polymer, generating a hierarchical structured (nano-in-nano-in-micro) vehi...