2 documents found, page 1 of 1
Paving the way for predictive diagnostics and personalized treatment of invasiv...
Coelho, Ana Oliveira; Rodrigues, Fernando José dos Santos; Campos Junior, António; Lacerda, João F.; Carvalho, Agostinho; Cunha, CristinaInvasive aspergillosis (IA) is a life-threatening fungal disease commonly diagnosed among individuals with immunological deficits, namely hematological patients undergoing chemotherapy or allogeneic hematopoietic stem cell transplantation. Vaccines are not available, and despite the improved diagnosis and antifungal therapy, the treatment of IA is associated with a poor outcome. Importantly, the risk of infecti...
PTX3-based genetic testing for risk of aspergillosis after lung transplant
Cunha, Cristina; Monteiro, Alexandre A.; Coelho, Ana Oliveira; Kühne, Juliana; Rodrigues, Fernando José dos Santos; Sasaki, Sergio D.; Schio, Sadi M.[Excerpt] We read with interest the article by Wójtowicz et al [1], and would like to comment on it and to share findings from our complementary study. We have recently established genetic variation in the long pentraxin 3 (PTX3) as a major determinant of susceptibility to invasive aspergillosis (IA) after hematopoietic stem cell transplant [2]. Wójtowicz et al are the first to uncover similar findings in solid...