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Dissemination of mycobacteria to the thymus renders newly generated T cells tol...

Nobrega, Claudia; Roque, Susana; Nunes-Alves, Cláudio; Coelho, Angela; Medeiros, Irene; Castro, António G.; Appelberg, Rui; Correia-Neves, M

The ability of the thymus to generate a population of T cells that is, for the most part, self-restricted and self-tolerant depends to a great extent on the Ags encountered during differentiation. We recently showed that mycobacteria disseminate to the thymus, which raised the questions of how mycobacteria within the thymus influence T cell differentiation and whether such an effect impacts host-pathogen intera...

Date: 2010   |   Origin: RepositóriUM - Universidade do Minho
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