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Management of Airway Remodeling in a Mouse Model of Allergic Airways Inflammati...
Fragoso,Felipe Yukio Ishikawa; Michelotto,Pedro Vicente; Angulski,Addeli Bez Batti; Leite,Lidiane Maria Boldrini; Senegaglia,Alexandra CristinaAbstract: Asthma is a chronic respiratory disease affecting 300 million people worldwide. It results in several structural changes in the airways, which are minimally accessible in clinical practice. Cell therapy using mesenchymal stromal cells (MSCs) is a promising strategy for treating asthma due to the paracrine activity of MSCs, which influences tissue regeneration and modulates the immune response. Studies...
Waist Circumference is Associated with Blood Pressure in Children with Normal B...
Pazin,Daiane Cristina; Rosaneli,Caroline Filla; Olandoski,Márcia; Oliveira,Edna Regina Netto de; Baena,Cristina Pellegrino; Figueredo,Alyne SAbstract Background: The prevalence of childhood obesity and associated conditions, such as hypertension, has become a major problem of public health. Although waist circumference (WC) is a marker of cardiovascular risk in adults, it is unclear whether this index is associated with cardiovascular risk factors in children. Objective: Our aim was to evaluate the association between increased WC and elevated blood...
Impact of anti-TNF agents in postoperative complications in Crohn's disease: a ...
Saab,Mansur; Saab,Bárbara; Olandoski,Márcia; Coy,Cláudio Saddy Rodrigues; Kotze,Paulo GustavoThe real impact of biological therapy (anti-TNF agents) in abdominal operations secondary to Crohn's disease is a matter of debate in the international literature. Several studies demonstrated that there can be an increase in postoperative complications in patients previously treated with these agents. On the other hand, the majority of studies published over the last years question this effect, and did not dem...
Risk factors for postoperative endoscopic recurrence in Crohn's disease: a Braz...
Barcelos,Ivan Folchini de; Silva,Rodolff Nunes da; Teixeira,Fábio Vieira; Albuquerque,Idblan Carvalho de; Saad-Hossne,Rogério; Ropelato,Renato VismaraIntroduction: Postoperative endoscopic recurrence (PER) is the initial event after intestinal resection in Crohn's disease (CD), and after a few years most patients present with progressive symptoms and complications related to the disease. The identification of risk factors for PER can help in the optimization of postoperative therapy and contribute to its prevention. Methods: Retrospective, longitudinal, mult...
Comparative analysis of adverse events between infliximab and adalimumab in Cro...
Kotze,Paulo Gustavo; Akiyoshi,Fernando Kenji; Luvizotto,Mateus; Olandoski,Márcia; Kotze,Lorete Maria da Silva; Coy,Cláudio Saddy RodriguesINTRODUCTION: Data is scarce regarding adverse events (AE) of biological therapy used in the management of Crohn's Disease (CD) among Brazilian patients. OBJECTIVES: To analyse AE prevalence and profile in patients with CD treated with Infliximab (IFX) or Adalimumab (ADA) and to verify whether there are differences between the two drugs. METHOD: Retrospective observational single-centre study of CD patients on ...
Revascularização do miocárdio minimamente invasiva videoassistida
Milani,Rodrigo Mussi; Brofman,Paulo; Guimarães,Maximiliano; Olandoski,Márcia; Meister Filho,Hugo; Baggio,Thales; Domingues,Maria FernandaFUNDAMENTO: De um modo geral, as operações estão cada vez menos invasivas e a cirurgia cardíaca começa a seguir por este caminho. OBJETIVO: Avaliar a evolução de cem pacientes submetidos à operação de revascularização do miocárdio minimamente invasiva. MÉTODOS: O acesso ao coração deu-se através de pequena toracotomia lateral no 4º espaço intercostal esquerdo, com 6 cm, iniciando-se ao nível do mamilo. Pelo mes...
Tendência de mortalidade por infarto agudo do miocárdio em Curitiba (PR) no per...
Baena,Cristina Pellegrino; Olandoski,Márcia; Luhm,Karin Regina; Costantini,Constantino Ortiz; Guarita-Souza,Luiz César; Faria-Neto,José RochaFUNDAMENTO: O Infarto Agudo do Miocárdio (IAM) é a principal causa isolada de óbito entre as doenças crônicas não transmissíveis no Brasil. O conhecimento das tendências de mortalidade é necessário para o planejamento de estratégias de prevenção. OBJETIVO: Avaliar a tendência de mortalidade por infarto do miocárdio no período de 1998 a 2009 na cidade de Curitiba (PR), sua distribuição por gênero, faixa etária e...
Epidemiological profile of 175 patients with Crohn's disease submitted to biolo...
Hardt,Marcelo Rassweiler; Kotze,Paulo Gustavo; Teixeira,Fabio Vieira; Ludvig,Juliano Coelho; Malluta,Everson Fernando; Kleinubing Junior,HarryINTRODUCTION: There is currently an increasing use of biological agents in the management of Crohn's disease (CD). There is lack of data regarding the epidemiological profile of patients on infliximab (IFX) and adalimumab (ADA) for CD in Brazil. OBJECTIVE: To identify the epidemiological characteristics of patients with CD who underwent biological therapy. METHOD: Retrospective multicenter study, with CD patien...
Disfunção do homoenxerto pulmonar utilizado na reconstrução do trato de saída d...
Lenzi,Andréa Weirich; Olandoski,Márcia; Ferreira,Wanderley Saviolo; Sallum,Fabio Said; Miyague,Nelson ItiroFUNDAMENTO: O homoenxerto pulmonar tem sido utilizado como uma opção na correção de cardiopatia congênita com obstrução da via de saída do ventrículo direito. Os resultados em longo prazo, no entanto, mostram-se pouco satisfatórios. OBJETIVO: Identificar os fatores de risco associados à disfunção e à falência do homoenxerto pulmonar. MÉTODOS: Estudo em crianças submetidas à ampliação da via de saída do ventrícu...
Antibodies anti-Saccharomyces cerevisiae (ASCA) do not differentiate Crohn's di...
Kotze,Lorete Maria da Silva; Nisihara,Renato Mitsunori; Utiyama,Shirley Ramos da Rosa; Kotze,Paulo Gustavo; Theiss,Petra Mirella; Olandoski,MárciaCONTEXT: Anti-Saccharomyces cerevisiae antibodies (ASCA), considered serologic markers for Crohn's disease, were described in patients with celiac disease, disappearing after a gluten-free diet. OBJECTIVES: Evaluation of ASCA positivity in patients with Crohn's disease and celiac disease in relation to healthy individuals. METHODS: A total of 145 individuals were studied: 36 with Crohn's disease and 52 with cel...