6 documents found, page 1 of 1
Shotgun proteomics of red blood cells from obstructive sleep apnea patients und...
Coelho, Cristina Valentim; Osório, Hugo; Vaz, Fatima; Neves, Sofia; Pinto, Paula; Barbara, Cristina; Penque, DeborahObstructive Sleep Apnea (OSA) syndrome is characterized by recurrent episodes of apneas and hypopneas during sleep, leading to recurrent intermittent hypoxia and sleep fragmentation. No treated OSA can result in metabolic and cardiovascular diseases. By 2D gel-based proteomics approach we have demonstrated that OSA can cause alterations in the red blood cells (RBC) proteome that may be associated with OSA outco...
Investigating the impact of COVID-19 vaccines on the red blood cell immune func...
Saraiva, Joana; Coelho, Cristina Valentim; Vaz, Fátima; Antunes, Marilia; Neves, Sofia; Ricardo, Peliano; Andrade, Odília; Miranda, ArmandinaThe role of red blood cells (RBC) in the immune system is increasingly recognized. However, RBC-derived molecules with an immunomodulatory role in health and disease, as well as in vaccine immunogenicity are still poorly investigated. Taking as a model the emergent COVID-19 vaccines, we aimed to investigate whether vaccines induce proteome and/or metabolome changes in RBCs able to affect T-cell immune activity,...
Evening and morning alterations in obstructive sleep apnea red blood cell proteome
Feliciano, Amélia; Vaz, Fátima; Coelho, Cristina Valentim; Torres, Vukosava M.; Silva, Rita; Prosinecki, Vesna; Alexandre, Bruno M.; Almeida, AndreiaThis article presents proteomics data referenced in [1] Using proteomics-based evaluation of red blood cells (RBCs), we have identified differentially abundant proteins associated with Obstructive Sleep Apnea Syndrome (OSA). RBCs were collected from peripheral blood of patients with moderate/severe OSA or snoring at pre- (evening) and post-night (morning) polysomnography, so that proteome variations between the...
Evening and morning peroxiredoxin-2 redox/oligomeric state changes in obstructi...
Feliciano, Amélia; Vaz, Fátima; Torres, Vukosava M.; Coelho, Cristina Valentim; Silva, Rita; Prosinecki, Vesna; Alexandre, Bruno M.; Carvalho, Ana S.We have examined the effects of Obstructive Sleep Apnea (OSA) on red blood cell (RBC) proteome variation at evening/morning day time to uncover new insights into OSA-induced RBC dysfunction that may lead to OSA manifestations. Dysregulated proteins mainly fall in the group of catalytic enzymes, stress response and redox regulators such as peroxiredoxin 2 (PRDX2). Validation assays confirmed that at morning the ...
Validação de potenciais biomarcadores proteómicos na Síndrome da Apneia Obstrut...
Coelho, Cristina Valentim[PT] A Síndrome da Apneia Obstrutiva do Sono (SAOS) é um distúrbio respiratório muito prevalente na população em geral, com graves repercussões na saúde e na qualidade de vida dos doentes. A Proteómica tem vindo a ser aplicada no estudo da SAOS na pesquisa de novos biomarcadores de diagnóstico, prognóstico, monitorização e/ou alvo terapêutico para esta doença. Estudos preliminares realizados no Laboratório de P...
Validação de potenciais biomarcadores proteómicos na Síndrome da Apneia Obstrut...
Coelho, Cristina ValentimA Síndrome da Apneia Obstrutiva do Sono (SAOS) é um distúrbio respiratório muito prevalente na população em geral, com graves repercussões na saúde e na qualidade de vida dos doentes. A Proteómica tem vindo a ser aplicada no estudo da SAOS na pesquisa de novos biomarcadores de diagnóstico, prognóstico, monitorização e/ou alvo terapêutico para esta doença. Estudos preliminares realizados no Laboratório de Proteó...