3 documents found, page 1 of 1
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypano...
Elias, Paula Regina; Coelho, Gleicekelly Silva; Xavier, Viviane Flores; Sales Júnior, Policarpo Ademar; Romanha, Alvaro JoséA series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected c...
Síntese, modelagem molecular e avaliação da atividade tripanossomicida in vitro...
Coelho, Gleicekelly SilvaPrograma de Pós-Graduação em Química. Departamento de Química, Instituto de Ciências Exatas e Biológicas, Universidade Federal de Ouro Preto.; A doença de Chagas é uma infecção grave causada pelo protozoário Trypanosoma cruzi, através do contato direto com as fezes dos insetos vetores (triatomíneos ou barbeiros). Essa doença acomete cerca de 9,8 a 11 milhões de pessoas em 21 países da América Latina. A principa...
Synthesis of 3,5-Diarylisoxazole derivatives and evaluation of in vitro trypano...
Souza, Aline Aparecida Nunes de; Xavier, Viviane F.; Coelho, Gleicekelly Silva; Sales Júnior, Policarpo Ademar; Romanha, Alvaro JoséChagas disease is included in the neglected tropical diseases list and is endemic to 21 Latin American countries. The two drugs currently available for treating Chagas disease are nifurtimox and benznidazole and both result in many significant side effects. The study describes the synthesis and biological evaluation of 3,5-disubstituted isoxazoles. Isoxazoles were obtained by reaction of flavones and hydroxylam...