7 documents found, page 1 of 1
Leveraging the future of diagnosis and management of diabetes: from old indexes...
Meneses, MJ; Patarrão, R; Pinheiro, T; Coelho, I; Carriço, N; Marques, AC; Romão, A; Nabais, J; Fortunato, Elvira; Raposo, JF; Macedo, PIn this review, we summarize and discuss indexes that have been used in epidemiological studies and in the clinical practice
Lenalidomide is effective and safe for the treatment of patients with relapsed ...
João, C; Freitas, J; Gomes, F; Geraldes, C; Coelho, I; Neves, M; Lúcio, P; Esteves, S; Esteves, GPatients with multiple myeloma (MM) and severe renal impairment (SRI) have shorter survival than MM patients without renal failure. Although lenalidomide is a highly active drug, this immunomodulatory agent is frequently neglected in this context due to its predominant renal clearance and, consequently, an increased risk of toxicity. This risk might be overcome with the proper lenalidomide dose adjustment to re...
The effect of cooking methods on the mineral content of quinoa (Chenopodium qui...
Mota, C; Nascimento, A. C; Santos, M; Delgado, I; Coelho, I; Rego, A; Matos, A. S; Torres, Duarte; Castanheira, IIn this study, we assessed the impact of two cooking methods, steaming and boiling, through the true retention (%TR) of minerals in pseudocereals and rice (varieties Indica and Japonica). Mineral content was determined by ICP-OES. Cooking methods have an impact on mineral composition of pseudocereals with losses up to 20%. QuinoaŽs %TR varied from 100% (manganese, phosphorus and iron) in steaming, to 83% (coppe...
Long-term survival in multiple myeloma.
João, C; Costa, C; Coelho, I; Vergueiro, MJ; Ferreira, M; Silva, MGKEY CLINICAL MESSAGE: The survival of multiple myeloma patients has improved very significantly over the last decade. Still median overall survival is inferior to 5 years. A small proportion of patients survive longer than 10 years. In this paper we discuss four cases illustrating the nonhomogeneous clinical presentation and evolution of this subset of patients. Surprisingly, these long survivors do not always ...
A whole genome screen for association with multiple sclerosis in Portuguese pat...
Santos, M; Pinto-Basto, J; Rio, ME; Sá, MJ; Valença, A; Sá, A; Dinis, J; Figueiredo, J; Bigotte de Almeida, L; Coelho, I; Sawcer, S; Setakis, EMultiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these...
Snoring in Portuguese primary school children
Ferreira, AM; Clemente, V; Gozal, D; Gomes, A; Pissarra, C; César, H; Coelho, I; Silva, CF; Azevedo, MHOBJECTIVE: To determine the prevalence of snoring and its potential associations with sleep problems, such as daytime symptoms, medical conditions, school performance, and behavioral disturbances in Portuguese children attending primary school. METHODS: A previously validated questionnaire was sent to the parents of 1381 children attending primary schools in a parish of Coimbra, Portugal. To assess behavioral d...
Acromegaly with the sleep apnea syndrome.
Ferreira, A M; César, M H; Pissarra, C; dos Santos, F J; Moita, J; Coelho, I; Azevedo, M HThe authors present the clinical of a male patient aged 45 years whose main complaints were loud snoring and excessive daytime sleepiness. Polysomnographic study revealed a sleep obstructive apnea syndrome with an apnea/hypopnea index of 86.5. After being treated with nasal continuous positive air pressure, (12 cm H2O), the apneas ended and sleep architecture was corrected. Physical examination also indicated t...