10 documents found, page 1 of 1
Extinction or coexistence in periodic Kolmogorov systems of competitive type
Coelho, Isabel; Rebelo, Carlota; Sovrano, ElisaWe study a periodic Kolmogorov system describing two species nonlinear competition. We discuss coexistence and extinction of one or both species, and describe the domain of attraction of nontrivial periodic solutions in the axes, under conditions that generalise Gopalsamy conditions. Finally, we apply our results to a model of microbial growth and to a model of phyto-plankton competition under the e_ect of toxins.
Conceção de modelo e aplicação de avaliação de práticas ágeis
Coelho, Isabel; Martins, Paula Ventura; Reis, LeonildeA orientação à criação de maior valor percecionado e da proximidade com os seus clientes e mercados, tem conduzido as organizações a tornarem-se cada vez mais ágeis nas suas estruturas e processos de negócio, identificando áreas de ineficiência e de pouca eficácia em termos de criação de valor junto dos seus clientes (internos/externos) e mercados. O artigo tem por objetivo a apresentar um modelo de avaliação (...
Avaliação do risco nutricional do doente cirúrgico
Coelho, IsabelO presente relatório surge no âmbito do 5º Curso de Mestrado em Enfermagem Especialização em Gestão de Unidades de Saúde na Escola Superior de Saúde de Portalegre sob a Orientação da Professora Graça Gama Pereira para a obtenção do grau de Mestre. No âmbito do estágio realizado no serviço de cirurgia geral tira 2 do Hospital do Espírito Santo de Évora, EPE, desenvolvi um Projeto sob a temática “Avaliação do Ris...
Heterogeneidade Clínica de 6 Casos com a Mutação «MELAS» A3243G do DNA Mitocond...
Vilarinho, Laura; Rodrigues, Lurdes; Coelho, Isabel; Rocha, Hugo; Pires, M. Melo; Guimarães, AntónioOs autores descrevem três casos com apresentação clínica atípica de MELAS, assim como dois membros oligossintomáticos e um assintomático das duas famílias portadores da mutação A3243G do tRNAL"(" do DNA mitocondrial. Em todos os casos, esta mutação pontual associada a doenças com hereditariedade materna, estava presente em heteroplasmia.
Positive Solutions of the Dirichlet Problem for the One-dimensional Minkowski-C...
Coelho, Isabel; Corsato, Chiara; Obersnel, Franco; Omari, PierpaoloWe discuss existence and multiplicity of positive solutions of the Dirichlet problem for the quasilinear ordinary differential equation-(u' / root 1 - u'(2))' = f(t, u). Depending on the behaviour of f = f(t, s) near s = 0, we prove the existence of either one, or two, or three, or infinitely many positive solutions. In general, the positivity of f is not required. All results are obtained by reduction to an eq...
NR4A2 and schizophrenia: Lack of association in a Portuguese/Brazilian study
Ruano, Dina; Macedo, António; Dourado, Ana; Soares, Maria João; Valente, José; Coelho, Isabel; Santos, Vítor; Azevedo, Maria Helena; Goodman, AnnThe present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients. The human Nur-related receptor 1, NR4A2, is an orphan nuclear receptor that can be constitutively active as a transcription factor and for which no natural ligand has yet been identified. Alone or with retinoid X receptor, RXR, NR4A2 influences the expression of several genes important for human ...
Lack of association or linkage disequilibrium between schizophrenia and polymor...
Ambrósio, Alda M.; Kennedy, James L.; Macciardi, Fabio; Coelho, Isabel; Soares, Maria J.; Oliveira, Catarina R.; Pato, Carlos N.Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained...
NR4A2 and schizophrenia: lack of association in a portuguese/brazilian study
Ruano, Dina; Macedo, António; Dourado, Ana; Soares, Maria João; Valente, José; Coelho, Isabel; Santos, Vítor; Azevedo, Maria Helena; Goodman, AnnThe present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients. The human Nur-related receptor 1, NR4A2, is an orphan nuclear receptor that can be constitutively active as a transcription factor and for which no natural ligand has yet been identified. Alone or with retinoid X receptor, RXR, NR4A2 influences the expression of several genes important for human ...
Genotypes at the APOE and SCA2 loci do not predict the course of multiple scler...
Santos, Mónica; Costa, Maria do Carmo; Rio, Maria Edite; Sá, Maria José; Monteiro, Marta; Valença, Angela; Sá, Alfredo; Dinis, José; Figueiredo, JoséMultiple sclerosis (MS) is a demyelinating disease that affects about one in 500 young Europeans. In order to test the previously proposed influence of the APOE and SCA2 loci on susceptibility to MS, we studied these loci in 243 Portuguese patients and 192 healthy controls and both parents of 92 patients. We did not detect any significant difference when APOE and SCA2 allele frequencies of cases and controls we...
Evidence for linkage disequilibrium between the alpha 7-nicotinic receptor gene...
Xu, Junzhe; Pato, Michele T.; Torre, Camille Dalla; Medeiros, Helena; Carvalho, Célia; Basile, Vincenzo S.; Bauer, Amy; Dourado, Ana; Valente, JoséRecent studies have suggested that the alpha 7-nicotinic receptor gene (CHRNA7) may play a role in the pathogenesis of schizophrenia. The alpha 7-nicotinic receptor gene (CHRNA7) is involved in P50 auditory sensory gating deficits, and the genomic locus for this gene lies in the chromosome 15q13-14 regions. The human gene is partially duplicated (exons 5-10) with four novel upstream exons. The marker D15S1360 h...