10 documents found, page 1 of 1
Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistan...
Costa, B; Coelho, J; Silva, V; Shahrour, H; Costa, NA; Ribeiro, AR; Santos, SG; Costa, F; Martínez-de-Tejada, G; Monteiro, C; Martins, MCLInfection is one of the major issues associated with the failure of orthopedic devices, mainly due to implant bacterial colonization, biofilm formation, and associated antibiotic resistance. Antimicrobial peptides (AMP) are a promising alternative to conventional antibiotics given their broad-spectrum of activity, low propensity to induce bacterial resistance, and ability to modulate host immune responses. Dhva...
Síndrome de hemiconvulsión-hemiplejía-epilepsia: caso clínico y uso de dextrome...
Coelho, J; Santos, T; Ezequiel, M; Luis, C; Levy, A
Neurodevelopmental Outcome Predictors of Term Newborns With Neonatal Seizures
Martins, R; Coelho, J; Santos, T; Moreno, T; Quintas, S; Levy, AIntroduction: The concrete burden of neonatal seizures in neurodevelopmental outcome of term newborns is still unknown in literature. The aim of this study was to describe prognostic predictors in neonatal seizures. Subjects and methods: Observational prospective study of term neonates with clinical seizures from a tertiary center (2009-2018). Adverse outcome was determined as death, global developmental delay,...
Extensive Linear Scleroderma en Coup De Sabre With Exertion-Induced Hemiplegic ...
Martins, M; Quintas, S; Coelho, J; Santos, T; Levy, AWe report the case of a 9-year-old girl with linear scleroderma en coup de sabre (LSCS) who developed progressive white matter involvement, presenting as intractable hemiplegic migraine-like attacks induced by exercise. After a period of severely aggressive course, clinical and radiological stabilization was achieved under immunosuppressant treatment. Intrathecal synthesis of IgG and lymphocytic pleocytosis pro...
Hemiconvulsion-hemiplegia-epilepsy Syndrome: Case Report and Use of Dextrometho...
Coelho, J; Santos, T; Ezequiel, M; Luís, C; Levy, A
Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders
Correia, CT; Conceição, IC; Oliveira, B; Coelho, J; Sousa, I; Sequeira, AF; Almeida, J; Café, C; Duque, F; Mouga, S; Roberts, W; Gao, K; Lowe, JKBACKGROUND: Validating the potential pathogenicity of copy number variants (CNVs) identified in genome-wide studies of autism spectrum disorders (ASD) requires detailed assessment of case/control frequencies, inheritance patterns, clinical correlations, and functional impact. Here, we characterize a small recurrent duplication in the annexin A1 (ANXA1) gene, identified by the Autism Genome Project (AGP) study. ...
A Idade é uma Variável Preditora da Funcionalidade após Acidente Vascular Cereb...
Tomás, R; Cláudio, S; Coelho, J; Marreiros, H; Bártolo, M; Santos, R; Lorga, S; Santos, S; Veiga, EExistem diversos factores que podem influenciar o prognóstico funcional nos doentes com Acidente Vascular Cerebral (AVC), nomeadamente o hemisfério afectado, severidade do deficit neurológico inicial, presença de comorbilidades, etiologia, entre outros. A idade como factor preditivo na reabilitação destes doentes tem sido alvo de controvérsia. O objectivo deste trabalho foi avaliar a idade como variável prediti...
Abcessos Renais - Revisão
Murinello, A; Mendonça, P; Correia, R; Rocha Mendes; Albergaria, M; Neta, J; Coelho, J; Lourenço, SBaseados num caso de associação de abcessos renal, perirrenal e de quisto renal infectado, ocorrendo após biopsia prostática, os autores fazem revisão bibliográfica dos abcessos renais, classificados segundo características anatómicas perinéfrico, cortical e cortico- -medular (nefrite bacteriana aguda focal/multifocal, pielonefrite enfisematosa e pielonefrite xantogranulomatosa). Os abcessos renais são mais fre...
Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n alle...
Silveira, I; Miranda, C; Guimarães, L; Moreira, MC; Alonso, I; Mendonça, P; Ferro, A; Pinto-Basto, J; Coelho, J; Ferreirinha, F; Poirier, JBACKGROUND: Ten neurodegenerative disorders characterized by spinocerebellar ataxia (SCA) are known to be caused by trinucleotide repeat (TNR) expansions. However, in some instances the molecular diagnosis is considered indeterminate because of the overlap between normal and affected allele ranges. In addition, the mechanism that generates expanded alleles is not completely understood. OBJECTIVE: To examine the...
Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n alle...
Silveira, I; Miranda, C; Guimarães, L; Moreira, MC; Alonso, I; Mendonça, P; Ferro, A; Pinto-Basto, J; Coelho, J; Ferreirinha, F; Poirier, J; Vale, JBACKGROUND: Ten neurodegenerative disorders characterized by spinocerebellar ataxia (SCA) are known to be caused by trinucleotide repeat (TNR) expansions. However, in some instances the molecular diagnosis is considered indeterminate because of the overlap between normal and affected allele ranges. In addition, the mechanism that generates expanded alleles is not completely understood. OBJECTIVE: To examine the...