52 documents found, page 1 of 6
Gold nanoparticles: a promising next-generation tool for breast cancer photothe...
Ferreira-Gonçalves, Tânia; Costa, Eduardo; Coelho, João; Gaspar, Maria Manuela; Ascensão, Lia; Ferreira-Santos, Pedro; Faísca, Pedro; Figueiredo, IsabelAuNPs show suitable mean sizes and maximum absorbance peaks to be used for PTT when locally administered. AuNPs show no toxicity either in breast cancer cell lines or red blood cells. Laser irradiation proved to be safe when applied alone. Combining EGF-conjugated AuNPs with laser irradiation resulted in a reduction of 33% in MCF-7 cells viability. The animal model was successfully developed (all animals develo...
Green exfoliation of 2D nanomaterials using cyrene as a solvent
Moreira, Pedro; Mendes, João; Calmeiro, Tomás; Nunes, Daniela; Carvalho, David; Kelly, Adam; Águas, Hugo; Fortunato, Elvira; Martins, RodrigoLiquid-phase exfoliation (LPE) is a versatile and scalable method for producing high-quality two-dimensional materials (2DMs). However, commonly used solvents such as dimethylformamide (DMF) or N-methyl-2-pyrrolidone (NMP) are highly toxic, limiting their potential for large-scale industrial applications. In this study, we address this challenge using Cyrene (dihydrolevoglucosenone), a nontoxic and biodegradabl...
Retinopatia Diabética - Orientações Clínicas 2023
Henriques, José; Pessoa, Bernardete; Figueira, João; Nascimento, João; Coelho, João; Ferreira, André; Rodrigues, Diogo; Gonçalves, Luís; Medeiros, MarcoDocumento: RD-gdl 0010 GER Portugal versão 1.2 Out-2023 (Este Documento esteve em discussão no GER e na SPO até 31 de Outubro de 2023 para recolha de opinião de todos os interessados de forma a melhorar o seu conteúdo e obter o maior consenso possível. A todos os colegas que deram o seu contributo, o grupo de trabalho agradece a colaboração.)
Os benefícios do desporto escolar de badminton em alunos com índice de massa co...
Coelho, JoãoO Relatório Final de Estágio enquadra-se no âmbito da Prática de Ensino Supervisionada (PES), parte do Mestrado em Ensino da Educação Física nos Ensinos Básico e Secundário, do Instituto Superior de Estudos Interculturais de Transdisciplinares do Instituto Piaget, em Almada. Este relatório descreve todo o desenvolvimento das competências adquiridas pelo professor estagiário no estágio pedagógico decorrido no an...
Intraocular Foreign Bodies: Clinical Characteristics and Prognostic Factors for...
Ferreira, André; Barbosa Ribeiro, Bruno; Coelho, João; Meireles, AngelinaIntroduction: Our objective was to evaluate the clinical presentation of patients with intraocular foreign bodies (IOFB) and establish prognostic factors for visual outcomes. Methods: Medical records of all patients undergoing surgery for an intraocular foreign body at Centro Hospitalar Universitário de Santo António in the last decade were retrospectively reviewed. Results: This study included 108 eyes of 107 ...
Integrated Use of Bioaccumulation, Genotoxic, and Haematological Endpoints to A...
Mieiro, Cláudia Leopoldina; Coelho, João; Reis, Ana; Castro, Diana; Figueira, Paula; Martinho, Filipe; Pardal, Miguel; Pereira, Eduarda; Pacheco, MárioBiosorption successfully remediates saline water contaminated with legacy contaminants, but its effects on the health of marine organisms remain unclear. Therefore, our aim was to address this knowledge gap with data on the accumulation ability, as well as the cytogenetic and biochemical effects in turbot (Scophthalmus maximus). To this end, we exposed turbot for seven days to a mixture of remediated metals (Re...
Phacoemulsification Alone or Combined with Descemet’s Stripping Without Endothe...
Vieira, Rita; Castro, Catarina; Coelho, João; Mesquita Neves, Miguel; Gomes, Miguel; Oliveira, LuísINTRODUCTION: To compare the efficacy of Descemet stripping without endothelial keratoplasty (DWEK) associated with phacoemulsification versus phacoemulsification alone in patients with moderate cataract and early-stage central Fuchs endothelial corneal dystrophy (FECD). METHODS: Retrospective, comparative, non-randomized study, including all patients with early-stage central FECD who were proposed to cataract ...
Integrated Use of Bioaccumulation, Genotoxic, and Haematological Endpoints to A...
Mieiro, Cláudia; Coelho, João; Reis, Ana Teresa; Castro, Diana; Figueira, Paula; Martinho, Filipe; Pardal, Miguel; Pereira, Eduarda; Pacheco, MárioBiosorption successfully remediates saline water contaminated with legacy contaminants, but its effects on the health of marine organisms remain unclear. Therefore, our aim was to address this knowledge gap with data on the accumulation ability, as well as the cytogenetic and biochemical effects in turbot (Scophthalmus maximus). To this end, we exposed turbot for seven days to a mixture of remediated metals (Re...
A dual-function SNF2 protein drives chromatid resolution and nascent transcript...
Carmo, Catarina; Coelho, João; Silva, Rui D.; Tavares, Alexandra; Boavida, Ana; Gaetani, Paola; Guilgur, Leonardo G.; Martinho, Rui GonçaloMitotic chromatin is largely assumed incompatible with transcription due to changes in the transcription machinery and chromosome architecture. However, the mechanisms of mitotic transcriptional inactivation and their interplay with chromosome assembly remain largely unknown. By monitoring ongoing transcription in Drosophila early embryos, we reveal that eviction of nascent mRNAs from mitotic chromatin occurs a...
A dual‐function SNF2 protein drives chromatid resolution and nascent transcript...
Carmo, Catarina; Coelho, João; Silva, Rui; Tavares, Alexandra; Boavida, Ana; Gaetani, Paola; Guilgur, Leonardo G; Martinho, Rui GoncaloMitotic chromatin is largely assumed incompatible with transcription due to changes in the transcription machinery and chromosome architecture. However, the mechanisms of mitotic transcriptional inactivation and their interplay with chromosome assembly remain largely unknown. By monitoring ongoing transcription in Drosophila early embryos, we reveal that eviction of nascent mRNAs from mitotic chromatin occurs a...