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Towards a Less Invasive Treatment for Head and Neck Cancer
Amaral, Mariana Neves; Neto, Íris; Cabral, Mitza; Nunes, Daniela; Fortunato, Elvira; Martins, Rodrigo; Rodrigues, Carla; Almeida, António P. deBackground/Objectives: Head and neck cancer (HNC) is the sixth most common cancer worldwide, with a high mortality, particularly from head and neck squamous cell carcinoma (HNSCC). Although some therapeutic strategies are available, they might cause severe side effects. For example, surgery may result in disfigurement and functional loss, severely impacting the patient’s quality of life. Thus, minimally invasiv...
Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for...
Ferreira-Gonçalves, Tânia; Iglesias-Mejuto, Ana; Linhares, Teresa; Coelho, João M. P.; Vieira, Pedro; Faísca, Pedro; Catarino, José; Ferreira, DavidAerogels are materials with unique properties, among which are low density and thermal conductivity. They are also known for their exquisite biocompatibility and biodegradability. All these features make them attractive for biomedical applications, such as their potential use in photothermal therapy (PTT). This technique is, yet, still associated with undesirable effects on surrounding tissues which emphasizes ...
The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part ...
Ferreira-Gonçalves, Tânia; Gaspar, Maria Manuela; Coelho, João M. P.; Marques, Vanda; Viana, Ana S.; Ascensão, Lia; Carvalho, LinaBreast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, the effectiveness of PTT can be improved by combining near infrar...
The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part ...
Ferreira-Gonçalves, Tânia; Gaspar, Maria Manuela; Coelho, João M. P.; Marques, Vanda; Viana, Ana S.; Ascensão, Lia; Carvalho, LinaBreast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, the effectiveness of PTT can be improved by combining near infrar...
Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined w...
Lopes, Joana; Ferreira-Gonçalves, Tânia; Figueiredo, Isabel V.; Rodrigues, Cecília M. P.; Ferreira, Hugo; Ferreira, David; Viana, Ana S.; Faísca, PedroThe global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyalur...
Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined w...
Lopes, Joana; Ferreira-Gonçalves, Tânia; Figueiredo, Isabel V.; Rodrigues, Cecília M. P.; Ferreira, Hugo; Ferreira, David; Viana, Ana S.; Faísca, PedroThe global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyalur...
Gold-Based Nanoplataform for the Treatment of Anaplastic Thyroid Carcinoma: A S...
Amaral, Mariana; Charmier, Adília J.; Afonso, Ricardo A.; Catarino, José; Faísca, Pedro; Carvalho, Lina; Ascensão, Lia; Coelho, João M. P.Anaplastic thyroid carcinoma (ATC) is a very rare subtype of thyroid carcinoma and one of the most lethal malignancies. Poor prognosis is mainly associated with its undifferentiated nature, inoperability, and failing to respond to the typically used therapies for thyroid cancer. Photothermal Therapy (PTT) entails using light to increase tissues’ temperature, leading to hyperthermia-mediated cell death. Tumours ...
Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined w...
Lopes, Joana; Ferreira-Gonçalves, Tânia; Figueiredo, Isabel V.; Rodrigues, Cecília M. P.; Ferreira, Hugo; Ferreira, David; Viana, Ana S.; Faísca, PedroThe global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyalur...
A Step Forward in Breast Cancer Research: From a Natural-Like Experimental Mode...
Costa, Eduardo; Ferreira-Gonçalves, Tânia; Cardoso, Miguel; Coelho, João M. P.; Gaspar, Maria Manuela; Faísca, Pedro; Ascensão, Lia; Cabrita, António S.Breast cancer is one of the most frequently diagnosed malignancies and common causes of cancer death in women. Recent studies suggest that environmental exposures to certain chemicals, such as 7,12-Dimethylbenzanthracene (DMBA), a chemical present in tobacco, may increase the risk of developing breast cancer later in life. The first-line treatments for breast cancer (surgery, chemotherapy or a combination of bo...
A Step Forward in Breast Cancer Research: From a Natural-Like Experimental Mode...
Costa, Eduardo; Ferreira-Gonçalves, Tânia; Cardoso, Miguel; Coelho, João M. P.; Gaspar, Maria Manuela; Faísca, Pedro; Ascensão, Lia; Cabrita, António S.Breast cancer is one of the most frequently diagnosed malignancies and common causes of cancer death in women. Recent studies suggest that environmental exposures to certain chemicals, such as 7,12-Dimethylbenzanthracene (DMBA), a chemical present in tobacco, may increase the risk of developing breast cancer later in life. The first-line treatments for breast cancer (surgery, chemotherapy or a combination of bo...