25 documents found, page 1 of 3
S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early ...
Ferreira, Catarina B.; Marttinen, Mikael; Coelho, Joana E; Paldanius, Kaisa M.A.; Takalo, Mari; Mäkinen, Petra; Leppänen, LuukasAlzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Previous studies have suggested a role for septin (SEPTIN) protein family members in AD-associated cellular processes. Here, we elucidated the potential role of presynap...
Immunopathology and Trypanosoma congolense parasite sequestration cause acute c...
De Niz, Mariana; Silva Pereira, Sara; Serre, Karine; Ouarné, Marie; Coelho, Joana E; Franco, Claudio; Figueiredo, Luisa M.Trypanosoma congolense causes a syndrome of variable severity in animals in Africa. Cerebral trypanosomiasis is a severe form, but the mechanism underlying this severity remains unknown. We developed a mouse model of acute cerebral trypanosomiasis and characterized the cellular, behavioral, and physiological consequences of this infection. We show large parasite sequestration in the brain vasculature for long p...
Inherited myopathies in patients from Sub-Saharan Africa: results from a retros...
Oliveira, Renato; Dourado Sotero, Filipa; Coelho, Joana E; Roque, Rafael; Moreno, Teresa; Oliveira Santos, MiguelThe clinical epidemiology of inherited myopathies in sub-Saharan Africa (SSA) is unknown but likely underdiagnosed due to problems of scientific research and social issues. We report a case series of patients born in SSA, evacuated to Portugal through an international health protocol and seen at a single neuromuscular disorders centre, between January/2004 and August/2021. We identified 9 patients (5 males), 35...
Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease...
Chegão, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido Ferreira, Mariana; Marques-Morgado, Inês; Fernandes Gomes, BárbaraAlpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson's disease (PD). Interestingly, a common molecular alteration among these disorders is the age-associated increase in protein glycation. ...
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of ...
Cristiano Brigas, Maria Helena; Ribeiro, Miguel; Coelho, Joana E; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, EmilieNeuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, but the contribution of the recently described meningeal immune population to AD pathogenesis remains to be addressed. Here, using the 3xTg-AD model, we report an accumulation of interleukin-17 (IL-17)-producing cells, mostly γδ T cells, in the brain and the meninges of female, but not male, mic...
Transection of the superior sagittal sinus enables bilateral access to the rode...
Dias, Marcelo; Marques-Morgado, Inês; Coelho, Joana E; Ruivo, Pedro; Lopes, Luisa V.; Remondes, MiguelStereotaxic access to brain areas underneath the superior sagittal sinus (SSS) is notoriously challenging. As a major drainage vessel, covering the whole extension of the sagittal fissure, the SSS impedes direct bilateral access to underlying regions for recording and stimulation probes, drug-delivery cannulas, and injection devices. We now describe a new method for transection and retraction of the SSS in rats...
Tapentadol prevents motor impairments in a mouse model of dyskinesia
Vaz, Rita; Chapela Pires, Diana; Coelho, Joana E; Lopes, Luisa V.; Ferreira, Joaquim J; Afonso, Nuno D.; Sousa, Sara; Outeiro, TiagoThe motor features in Parkinson's disease (PD) are associated with the degeneration of dopaminergic cells in the substantia nigra in the brain. Thus, the gold-standard in PD therapeutics still consists of dopamine replacement with levodopa. However, as the disease progresses, this therapeutic option becomes less effective and can be accompanied by levodopa-induced complications. On the other hand, several other...
Multicompartment microreactors prevent excitotoxic dysfunctions in rat primary ...
Armada-Moreira, Adam; Coelho, Joana E; Lopes, Luisa V.; Sebastião, Ana M; Städler, Brigitte; Vaz, Sandra H.Excitotoxicity is a cellular phenomenon that comprises the consequences of toxic actions of excitatory neurotransmitters, such as glutamate. This process is usually related to overproduction of reactive oxygen species (ROS) and ammonia (NH4+ ) toxicity. Platinum nanoparticle (Pt-NP)-based microreactors able to degrade hydrogen peroxide (H2 O2 ) and NH4+ , are previously described as a novel therapeutical approa...
Adenosine receptors as neuroinflammation modulators: role of A1 agonists and A2...
Martí Navia, Aleix; Dal Ben, Diego; Lambertucci, Catia; Spinaci, Andrea; Volpini, Rosaria; Marques-Morgado, Inês; Coelho, Joana E; Lopes, Luisa V.The pathological condition of neuroinflammation is caused by the activation of the neuroimmune cells astrocytes and microglia. The autacoid adenosine seems to be an important neuromodulator in this condition. Its main receptors involved in the neuroinflammation modulation are A1AR and A2AAR. Evidence suggests that A1AR activation produces a neuroprotective effect and A2AARs block prevents neuroinflammation. The...
The neuroprotective action of amidated-kyotorphin on amyloid β peptide-induced ...
Belo, Rita F.; Martins, Margarida L. F.; Shvachiy, Liana; Costa-Coelho, Tiago; de Almeida-Borlido, Carolina; Fonseca-Gomes, João; Neves, VeraKyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective agent, namely for Alzheimer's disease (AD). In fact, KTP levels were shown to be decreased in the cerebrospinal fluid of patients with AD, and recent data showed that intracerebroventricular (i.c.v.) injection of KTP ameliorates memor...