43 documents found, page 1 of 5
Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in ...
Coelho, M; Capela, J; Mendes, VM; Pacheco, J; Fernandes, MS; Amendoeira, I; Jones, JG; Raposo, L; Manadas, BThyroid cancer is a common malignancy of the endocrine system. Nodules are routinely evaluated for malignancy risk by fine needle aspiration biopsy (FNAB), and in cases such as follicular lesions, differential diagnosis between benign and malignant nodules is highly uncertain. Therefore, the discovery of new biomarkers for this disease could be helpful in improving diagnostic accuracy. Thyroid nodule biopsies w...
Eficácia de intervenções dietéticas e nutricionais na diabetes gestacional – re...
Coelho, M; Coutinho, J; Pinto, EIntrodução: A diabetes gestacional é uma das complicações mais comuns da gravidez, associada a altos níveis de inflamação. É caracterizada por alterações do metabolismo glicémico e lipídico num ambiente de inflamação de baixo grau. A terapêutica nutricional tem demonstrado ser coadjuvante ou alternativa ao tratamento farmacológico. Objetivos: Rever sistematicamente e avaliar criticamente as diretrizes mais rece...
Multiple Keratotic Projections on the Palms and Soles
Barbosa, J; Coelho, M; Joao, Apiny keratoderma (SKD) is a rare palmoplantar keratoderma that presents with few to numerous millimetric hyperkeratotic projections on the palms and soles. It has been described with both hereditary and acquired variants. The acquired form, which presents in older adults, has been associated with a variety of systemic diseases and malignant conditions. In patients suspected of having acquired spiny keratoderma,...
Transmural Remission Improves Clinical Outcomes Up to 5 years in Crohn's Disease
Raimundo Fernandes, S; Serrazina, J; Ayala Botto, I; Leal, T; Guimarães, A; Lemos Garcia, J; Rosa, I; Prata, R; Carvalho, D; Neves, J; Campelo, PIntroduction: Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. Methods: Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colon...
Epidemiological, Social and Economic Burden of Severe Hypoglycaemia in Patients...
Soares, AR; Coelho, M; Tracey, M; Carvalho, D; Silva-Nunes, JIntroduction: The aim of this review was to identify and review studies reporting on the epidemiological, social and economic impact associated with severe hypoglycaemia (SH) in people with diabetes mellitus (DM) in Portugal. Methods: A structured literature search was carried out in PubMed and Embase using a predefined selection criterion. Studies published in either Portuguese or English, between January 2010...
Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer
Coelho, M; Capela, J; Anjo, SI; Pacheco, J; Fernandes, MS; Amendoeira, I; Jones, JG; Raposo, L; Manadas, BDifferentiated thyroid cancer is the most common malignancy of the endocrine system. Although most thyroid nodules are benign, given the high incidence of thyroid nodules in the population, it is important to understand the differences between benign and malignant thyroid cancer and the molecular alterations associated with malignancy to improve detection and signal potential diagnostic, prognostic, and therape...
Multidrug-Resistant Bacteria in Diabetic Foot Infections: Experience from a Por...
Pessoa E Costa, T; Duarte, B; João, AL; Coelho, M; Formiga, A; Pinto, M; Neves, JIn recent years, the emergence of antibiotic resistant pathogens made increasingly difficult to establish appropriate empiric antimicrobial therapy protocols for acute diabetic foot infection (DFI) treatment. Early recognition of the population at-risk for multidrug-resistant (MDR) bacterial infection is of paramount importance in order to decrease large-spectrum antibiotic overuse. This study used retrospectiv...
The Potential of Metabolomics in the Diagnosis of Thyroid Cancer
Coelho, M; Raposo, L; Goodfellow, BJ; Atzori, L; Jones, J; Manadas, BThyroid cancer is the most common endocrine system malignancy. However, there is still a lack of reliable and specific markers for the detection and staging of this disease. Fine needle aspiration biopsy is the current gold standard for diagnosis of thyroid cancer, but drawbacks to this technique include indeterminate results or an inability to discriminate different carcinomas, thereby requiring additional sur...
Reshaping in vitro Models of Breast Tissue: Integration of Stromal and Parenchy...
Silva, PB; Coelho, M; Bidarra, SJ; Neves, SC; Barrias, CCBreast tissue consists of an epithelial parenchyma embedded in stroma, of heterogeneous and complex composition, undergoing several morphological and functional alterations throughout females' lifespan. Improved knowledge on the crosstalk between parenchymal and stromal mammary cells should provide important insights on breast tissue dynamics, both under healthy and diseased states. Here, we describe an advance...
Child suicide: The reality overcomes the myth
Oliveira, Adriana Leônidas de; Affini, Ester Passos; Cerveny, Ceneide Maria de Oliveira; Coelho, M; Schliemann, Ana LauraMade available in DSpace on 2019-09-12T16:57:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2000; Universidade de Taubaté (Unitau); Pontificia Univ Catolica, Sao Paulo, Brazil