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Trends in land cover and in pollen concentration of Quercus genus in Alentejo, ...

Galveias, Ana; Duarte, Ediclê; Raposo, Mauro; Costa, Maria João; Costa, Ana; Antunes, Célia

Mediterranean forests dominated by Quercus species are of great ecological and economic value. The Quercus pollen season, peaking in April, varies in concentration due to geographical and climatic factors and has a remarkable allergenic potential. This study investigates Quercus trends in the Alentejo region of Portugal and examines the influence of meteorological parameters on DPC, PSD and SPIn, as well as the...


Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids against C...

Carreiro, Elisabete; Costa, Ana; Burke, Anthony; Antunes, Célia; Gastalho, Carlos; Pereira, Florbela; Lopez, Oscar; Fernández-Bolaños, José G.

Combining the pharmacological properties of the 1,2,3-triazole and dihydropyrimidinone classes of compounds, two small families of mono- and di(1,2,3-triazole)-dihydropyrimidinone hybrids, A and B, were previously synthesized. The main objective of this work was to investigate the potential anti-Alzheimer effects of these hybrids. The inhibitory activities of cholinesterases (AChE and BuChE), antioxidant activi...


Chitosan- and chitosan-polaxamer 407 based nanoparticles: green nanotechnology ...

Carreiro, Elisabete; Antunes, Célia; Gastalho, C.; Craveiro, Alexandre

The chymotrypsin-like main protease (3CLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for cleavage of two viral polyproteins into 16 nonstructural pro- teins. Its catalytic activity is critical for the life cycle of the SARS-CoV-2, since the inhibition of the 3CLpro can effectively block the whole replication of the virus. The 3CLpro has a bell- shaped activity-pH profile w...


Relatório Final do projeto ALOP (ALT20-03-0145-FEDER-000004)

Salgado, Rui; Palma, Patrícia; Morais, M. Manuela; Almeida, Adelaide; Alvarenga, Paula; Antunes, Célia; Aranha, Sergio; Bárias, Samuel; Barrenho, Joel

O Projeto ALOP teve início formal a 25 de Maio de 2016 e terminou a 31 de dezembro de 2019. Neste relatório final procuramos dar conta das atividades efetuadas e principalmente dos resultados obtidos. A tarefa está facilitada pois o projeto, em conjunto com as sinergias geradas com outros projetos e as colaborações nacionais e internacionais dos vários membros da equipa permitiram a publicação de um invejável n...


THINK4JOBS Critical Thinking blended apprenticeships curricula

Mäkiö, Juho; Mäkiö, Elena; Pnevmatikos, Dimitriοs; Christodoulou, Panagiota; Payan Carreira, Rita; Georgiadou, Triantafyllia; Lithoxoidou, Angeliki

The current Report namely, the third Intellectual Output (IO3) describes 12 Critical Thinking (CT) blended apprenticeships curricula. The development of these curricula was enabled and enhanced through the training that was carried out for Higher Education (HE) Instructors and Labour Market Organisation (LMO) Tutors (IO2). In this training, the participants learned how to promote, develop, support, and assess c...


Outdoor airborne allergens: Characterization, behavior and monitoring in Europe

Grewling, Lukasz; Ribeiro, Helena; Antunes, Célia; Apangu, Godfrey; Çelenk, Sevcan; Costa, Ana; Eguiluz-Garcia, Ibon; Galveias, Ana; Roldan, Nestor

Aeroallergens or inhalant allergens, are proteins dispersed through the air and have the potential to induce allergic conditions such as rhinitis, conjunctivitis, and asthma. Outdoor aeroallergens are found predominantly in pollen grains and fungal spores, which are allergen carriers. Aeroallergens from pollen and fungi have seasonal emission patterns that correlate with plant pollination and fungal sporulation...


cEpiderm, a Canine Skin Analog Suitable for In Vivo Testing Replacement

Marques, Mariana; Nunes, João; Ustymenko, Bárbara; Fialho, Luísa; Martins, Luís; Burke, Anthony; Filho, Cesar; Craveiro, Alexandre; Costa, Ana

Skin is one of the organs most tested for toxicity and safety evaluation during the process of drug research and development and in the past has usually been performed in vivo using animals. Over the last few years, non-animal alternatives have been developed and validated epidermis models for human and rat skin are already available. Our goal was to develop a histotypical canine skin analog, suitable for non-a...


Development of a canine epidermis equivalent model for evaluation of sensitization

Marques, M; Nunes, J; Ustymenko, B; Lagoa, Tânia; Fialho, Luísa; Martins, Luís; Burke, Anthony; Souza, E; Filho, César; Craveiro, Alexandre; Costa, Ana

Background Canine atopic dermatitis (cAD) is a genetic-predisposed allergic and pruritic inflammatory skin condition, associated with sensitization to environmental allergens. Keratinocytes can produce several inflammatory mediators, in response to several other host mediators, antigens, and pathogens by virtue of their wide range of surface receptors, some of them dysregulated in cAD individuals. A histotypica...


Synthesis and Antiproliferative Activity of Novel Quercetin-1,2,3- Triazole Hyb...

Carreiro, Elisabete; Costa, Ana; Antunes, Célia

Twenty-three new quercetin-1,2,3-triazole hybrids were synthesized in good to quantitative yields via Cu(I)-catalyzed azide- alkyne cycloaddition reaction under microwave irradiation. These new hybrids contain a 1,4-disubstituted 1,2,3-triazole ring at the 3-OH posi- tion of quercetin whilst the remaining hydroxyl groups were either pro- tected as methyl or benzyl groups or left unprotected. All the querce- tin...


Carcinoma Hepatocelular e Colangiocarcinoma Síncronos num Fígado Cirrótico de E...

Borges, Ana Paula; Caseiro-Alves, Filipe; Antunes, Célia; Donato, Paulo

Durante a avaliação pré-transplante hepático de um doente de 59 anos com cirrose de etiologia alcoólica, foram detetados dois nódulos hepáticos com características imagiológicas compatíveis com carcinoma hepatocelular (CHC). Em tempos diferentes, foram ambos eficazmente submetidos a quimioembolização transarterial com doxorrubicina, permitindo ao doente continuar a cumprir critérios para transplante. O primeiro...

Date: 2023   |   Origin: Acta Radiológica Portuguesa

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