94 documents found, page 1 of 10
Bioactive peptides from milk proteins with antioxidant, anti-inflammatory, and ...
Borges, Thaís; Coelho, Pedro; Prudêncio, Cristina; Gomes, Ana; Gomes, Paula; Ferraz, Ricardo; Coelho, Pedro; Prudêncio, Cristina; Ferraz, RicardoPeptides from protein ingredients exhibit key biological activities, including antimicrobial, antihypertensive, antioxidant, anti-inflammatory, analgesic, and immunomodulatory effects. Aligning with the One Health approach, there is growing investment in promoting pet health and well-being. As a result, sustainable functional ingredients are increasingly essential for pet food development. In this work, peptide...
Development of a cellprofiler pipeline to evaluate adipocyte differentiation
Andrade, João; Torres, Sílvia; Coelho, Pedro; Coelho, PedroObesity is a complex chronic disease characterized by excessive body fat accumulation, with increasingly prevalence worldwide, burdening individuals and healthcare systems, thus urgent research is needed. (1,2) Adipocytes, the major cellular component of adipose tissue, are cells vastly used by the scientific community for in vitro studies of obesity. (3) Oil red O (ORO) staining and quantification is widely us...
A conversational agent for enhanced self-management after cardiothoracic surgery
Martins, Ana; Lapão, Luís Velez; Nunes, Isabel L.; Giordano, Ana Paula; Semedo, Helena; Vital, Clara; Silva, Raquel; Coelho, Pedro; Londral, AnaBackground: Enhanced self-management is crucial for long-term survival following cardiothoracic surgery. Objectives: This study aimed to develop a conversational agent to enhance patient self-management after cardiothoracic surgery. Methodology: The solution was designed and implemented following the Design Science Research Methodology. A pilot study was conducted at the hospital to assess the feasibility, usab...
Potential probiotic and functional properties of Brettanomyces strains isolated...
Areal-Hermida, Lara; Coelho, Pedro; Pichardo-Gallardo, Ángeles; Prudêncio, Cristina; Sieiro, CarmenKombucha, a beverage traditionally obtained through the fermentation of tea, is believed to have beneficial health properties. Therefore, characterizing the microorganisms responsible for this fermentation is essential to demonstrate its potential health benefits and to identify candidates for new probiotics. In this study, four probiotic yeast strains isolated from kombucha tea were identified, by the PCR-RFLP...
Development of a stable melanoma dual reporter cell line expressing Luciferase ...
Aguiar, Gonçalo; Torres, Sílvia; Prudêncio, Cristina; Soares, Raquel; Coelho, Pedro; Prudêncio, Cristina; Coelho, PedroMelanoma is the most aggressive and lethal form of skin cancer, with a high risk of metastatic spread. Obesity is recognized as a risk factor for various types of cancer. However, regarding melanoma, this association remains controversial. Obesity might act as a double-edged sword in melanoma, promoting primary tumour growth but at the same time limiting metastatic spread - the "obesity paradox”. Herein, we aim...
Vascular dysfunction in adipose tissue: Its impact on type 2 diabetes and cancer
Silva, Daniela Rosendo; Aguiar, Gonçalo; Luís, Carla; Soares, Raquel; Coelho, Pedro; Coelho, PedroThe overgrowth of adipose tissue is a major trigger for the development of other metabolic disorders, like insulin resistance, hypertension, type 2 diabetes, cardiovascular disease, and cancer. Among the causes of this association lies the fact that increased adiposity is accompanied by a nonfunctioning vascular component. Accordingly, vascular dysfunction within the adipose tissue is common in obesity and asso...
Brewing Mainly from Stale Bread: A Pale Ale Case Study
Coelho, Pedro; Prista, Catarina; Sousa, IsabelContemporary environmental concerns have led to the prioritization of sustainable pro- duction and material circularity, no matter what the industrial field of activity. Bread waste is a major element of overall food waste since, worldwide, bread remains a widespread staple food. A considerable proportion of bread consumption is of fresh, baked bread, consumed daily, generating substantial amounts of stale brea...
In vitro evaluation of peptides with potential antioxidant, anti-inflammatory a...
Borges, Thais; Ferraz, Ricardo; Coelho, Pedro; Prudêncio, Cristina; Gomes, Ana; Gomes, PaulaHypertension develops from genetic and environmental factors, and is exacerbated by disorders that increase systemic vascular resistance, like oxidative stress, inflammation and immune system dysfunction1,2. The search for natural compounds as an alternative or a complement to the drugs used to treat hypertension and other chronic diseases has gained momentum in recent years1 . One example is that of food-deriv...
Secretome of umbilical cord mesenchymal stem cells: Potential effects on melanoma
Fernandes, Pablo ; Gomes, Andreia ; Coelho, PedroMelanoma, a tumor resulting from the malignant transformation of melanocytes, is characterized by its aggressive nature and propensity to metastasize. Current treatment options for advanced melanoma are limited and mostly ineffective, highlighting the need for novel therapeutic approaches. Mesenchymal stem cells (MSCs) have increased considerable attention due to their anti-cancer and immunomodulatory propertie...
Impact of umbilical cord mesenchymal stromal/stem cell secretome and cord blood...
Sousa, André ; Coelho, Pedro; Leite, Fernanda ; Teixeira, Catarina ; Rocha, Ana Catarina ; Santos, Inês ; Baylina, Pilar; Fernandes, RubenProstate cancer (PCa) is the second most common malignancy in men, and the ffth leading cause of death worldwide. Mesenchymal stromal/stem cells (MSC) have been identifed in PCa, although contradictory efects in malignant transformation and tumor progression have been described. Since umbilical cord (UC) MSC and cord blood serum (CBS) are rich in numerous growth and anti-infammatory factors, UC-MSC secretome an...